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Multi-step reaction with 3 steps
1: caesium carbonate / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere
2: palladium on activated charcoal; hydrogen; sodium sulfite / ethanol; ethyl acetate / 24 h
3: 1 h / 130 °C
Multi-step reaction with 3 steps
1.1: barium hydroxide octahydrate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 20 h / 80 °C
2.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h
2.2: 20 h
3.1: 1 h / 130 °C
Multi-step reaction with 3 steps
1.1: caesium carbonate / 1,2-dimethoxyethane; water / 0.17 h / Inert atmosphere
1.2: 4 h / 90 °C / Inert atmosphere
2.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate; ethanol; water / 24 h
3.1: 1 h / 130 °C
Multi-step reaction with 3 steps
1: caesium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere
2: 5%-palladium/activated carbon; hydrogen / ethanol; water; ethyl acetate / 24 h
3: 1 h / 130 °C
Multi-step reaction with 3 steps
1: barium hydroxide octahydrate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 16 h / 80 °C
2: hydrogen; acetic acid / palladium 10% on activated carbon / ethanol / 24 h
3: 1 h / 130 °C
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); barium hydroxide octahydrate / water; 1,2-dimethoxyethane / 16 h / 80 °C
2: iron; ammonium chloride / ethanol; water / 2 h / 80 °C
3: 0.5 h / 130 °C
Multi-step reaction with 4 steps
1: diphenylether / 0.75 h / 255 °C
2: sodium hydroxide / ethanol / Reflux
3: trichlorophosphate / 4 h / Heating
4: ammonium hydroxide / tetrahydrofuran / 0.5 h / Cooling with ice
Multi-step reaction with 3 steps
1.1: diphenylether / 0.75 h / 255 °C
2.1: sodium hydroxide; water / ethanol / Reflux
2.2: 0.17 h / pH 4
3.1: trichlorophosphate / 20 °C / Heating
3.2: 0.5 h / Cooling with ice
Multi-step reaction with 3 steps
1.1: diphenylether / 0.33 h / Reflux
2.1: sodium hydroxide; water / ethanol; water / Reflux
2.2: 40 °C / pH 4
3.1: trichlorophosphate / 4 h / 20 °C / Heating
3.2: 0.5 h / Cooling with ice
Multi-step reaction with 4 steps
1: diphenylether / 0.5 h / Reflux
2: sodium hydroxide; ethanol / Reflux
3: trichlorophosphate / 4 h / Heating
4: ammonium hydroxide / tetrahydrofuran / 0.5 h / Cooling with ice
Multi-step reaction with 3 steps
1.1: diphenylether / 0.75 h / 255 °C
2.1: ethanol; sodium hydroxide / Reflux
2.2: pH 4
3.1: trichlorophosphate / N,N-dimethyl-formamide / 5 h / Reflux
3.2: 1 h / 0 - 5 °C
Multi-step reaction with 3 steps
1.1: diphenylether / 0.25 h / 280 °C / Microwave irradiation
2.1: sodium hydroxide; ethanol / 17 h / 80 °C
3.1: trichlorophosphate / 2 h / 100 °C
3.2: 0.5 h / 0 °C