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Chemical Structure| 130473-38-0 Chemical Structure| 130473-38-0

Structure of 130473-38-0

Chemical Structure| 130473-38-0

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Product Details of [ 130473-38-0 ]

CAS No. :130473-38-0
Formula : C9H12O4
M.W : 184.19
SMILES Code : O=C1OC(C)(C)OC(CC(C)=O)=C1
MDL No. :MFCD18800526

Safety of [ 130473-38-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 130473-38-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 130473-38-0 ]

[ 130473-38-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 79055-62-2 ]
  • [ 130473-38-0 ]
  • 2'-chloro-4-hydroxy-6,5'-dimethyl-[1,4']bipyridinyl-2-one sulfate salt [ No CAS ]
YieldReaction ConditionsOperation in experiment
57% Step A: Preparation of 2'-chloro-4-hydroxy-6,5'-dimethyl-[1,4']bipyridinyl-2-one To a screw top vial with rubber septa inset was added 2,2-dimethyl-6-(2-oxo-propyl)-[1,3]dioxin-4-one, prepared as described in Organic Letters, 11(21), 4910-4913; 2009, (500 mg, 2.7 mmol) and <strong>[79055-62-2]2-chloro-5-methyl-pyridin-4-ylamine</strong> (575 mg, 4 mmol, 1.5 eq). The mixture was dissolved in anhydrous 1,4-dioxane (10 mL). Once the mixture was homogeneous the vial was placed on a stirrer/hot plate preset to 90° C. The reaction vessel was heated at this temperature for 3.5 h. The reaction vial was removed from heat and analyzed by HPLC which showed that the reaction was >95percent complete. The vial was placed back on the hot plate. To the heated mixture was added H2SO4 (250 muL) and the reaction was heated for 1 h. The reaction vial was removed from the heat and after cooling to ambient temperature, the dioxane was removed by passing a stream of air over the top of the open vial to give a brown residue. Water (?4 mL) was added to the vial, and the mixture was stirred for 30 min. The resulting tan solid was filtered off with washing from additional water and the diethyl ether to give the desired product (531 mg, 57percent based on being the sulfate salt) as a tan solid which by HPLC was ?95percent pure: MS (ES) m/e 250 (M+H).
 

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