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Chemical Structure| 130525-62-1 Chemical Structure| 130525-62-1

Structure of 4-Am-dana
CAS No.: 130525-62-1

Chemical Structure| 130525-62-1

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Synonyms: Zanamivir amine

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Product Details of [ 130525-62-1 ]

CAS No. :130525-62-1
Formula : C11H18N2O7
M.W : 290.27
SMILES Code : O=C(C1=C[C@H](N)[C@@H](NC(C)=O)[C@H]([C@H](O)[C@H](O)CO)O1)O
Synonyms :
Zanamivir amine
MDL No. :MFCD20488591
InChI Key :NKENBBIXEGPQLS-UFGQHTETSA-N
Pubchem ID :445533

Safety of [ 130525-62-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 130525-62-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 130525-62-1 ]

[ 130525-62-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 1184-90-3 ]
  • [ 130525-62-1 ]
  • [ 139110-80-8 ]
  • 2
  • [ 130525-62-1 ]
  • [ 66356-40-9 ]
  • [ 139110-80-8 ]
  • 3
  • [ 166197-22-4 ]
  • [ 130525-62-1 ]
  • [ 139110-80-8 ]
YieldReaction ConditionsOperation in experiment
74.9% With sodium carbonate; In water; at 35℃; for 7h;Industrial scale; 1.4 kg of 2,3-didehydro-4-amino-4-acety lneuraminic acid (Formula la) was added 30l of glass reactor , 15 kg of water was added , then 1.3 kg of sodium carbonate was added, and followed by the addition 800 g of imidopyridine hydrochloride at 40 C , and reaction was carried out for 6 hours. the 8 kg of water was concentrated and 13 kg of isopropyl alcohol was added and stirred to precipitate a solid powder. filtered , washed with isopropanol and dried to obtain 67 g of crude Zanamivir . then recrystallized from isopropanol-water , filtrated , and dried to obtain a pharmaceutical grade of zanamivir (formula I) 1. kg Yield: 74.9%
 

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