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Chemical Structure| 1305324-90-6 Chemical Structure| 1305324-90-6

Structure of 1305324-90-6

Chemical Structure| 1305324-90-6

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Product Details of [ 1305324-90-6 ]

CAS No. :1305324-90-6
Formula : C16H17BrN2O2SSi
M.W : 409.37
SMILES Code : C[Si](C1=CC2=CC(Br)=CN=C2N1S(=O)(C3=CC=CC=C3)=O)(C)C
MDL No. :MFCD20487043

Safety of [ 1305324-90-6 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P264-P270-P301+P310+P330-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 1305324-90-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1305324-90-6 ]

[ 1305324-90-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 75-77-4 ]
  • [ 1001070-33-2 ]
  • [ 1305324-90-6 ]
YieldReaction ConditionsOperation in experiment
66% 5-Bromo-1-(phenylsulfonyl)-2-(trimethylsilyl)-1H-pyrrolo[2,3-b]pyridine To a well stirred solution of <strong>[1001070-33-2]5-bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine</strong> (6.0 g, 17.8 mmol) in dry THF (60 mL) was added LDA (2M in THF; 16.0 mL, 32 mmol) at -78 C. slowly over 15 min. The reaction mixture was stirred at -70 C. for 1 h and then cooled back to -78 C. Chlorotrimethylsilane (4.1 mL, 32 mmol) was added slowly, and the reaction mixture was allowed to warm to ambient temperature over 4 h (TLC monitoring: 20% ethyl acetate in hexanes). Solvent was removed under reduced pressure keeping temperature below 40 C. to give a residue. It was extracted with ethyl acetate (2*50 mL) and washed with water (40 mL), followed by brine (10 mL) and dried over sodium sulfate. The solvent was removed under reduced pressure to yield a brown solid which was purified by column chromatography using 10% ethyl acetate in hexanes to yield the title compound as a white solid (4.8 g, 66%). 1H NMR (CDCl3, 300 MHz): delta=0.51 (s, 9H), 6.72 (s, 1H), 7.47-4.59 (m, 3H), 7.91 (d, J=2.1 Hz, 1H), 8.09-8.12 (m, 2H), 8.37 (d, J=2.1 Hz, 1H).
 

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