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Chemical Structure| 130955-37-2 Chemical Structure| 130955-37-2
Chemical Structure| 130955-37-2

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Synonyms: m-PEG4-Ms

4.5 *For Research Use Only !

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Product Details of M-PEG5-ms

CAS No. :130955-37-2
Formula : C10H22O7S
M.W : 286.34
SMILES Code : COCCOCCOCCOCCOS(C)(=O)=O
Synonyms :
m-PEG4-Ms
MDL No. :MFCD30723269

Safety of M-PEG5-ms

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of M-PEG5-ms

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 130955-37-2 ]

[ 130955-37-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 130955-37-2 ]
  • [ 24985-85-1 ]
  • C20H29NO7 [ No CAS ]
YieldReaction ConditionsOperation in experiment
72% With potassium carbonate; In acetone; at 60℃; for 95h; Synthesis of Ethyl 5-O-mPEG4-indole Carboxylate 10 (n=4): A mixture of <strong>[24985-85-1]ethyl 5-hydroxyindole carboxylate</strong> 9 (1.0734 g, 5.13 mmol), mPEG4-OMs (690 mg, 2.41 mmol) and potassium carbonate (3.0361 mg, 21.97 mmol) in acetone (40 mL) was stirred 60 C. for 7 h. Additional quantities of mPEG4-OMs (897 mg, 3.13 mmol) were added. The mixture was stirred at 60 C. for another 17 h. More mPEG4-OMs (756 mg, 2.64 mmol) was added. After 23 h at 60 C., mPEG4-OMs (438 mg, 1.48 mmol) and acetone (30 mL) were added. The mixture was stirred at 60 C. for two days. The mixture was cooled to room temperature, filtered. The solid was washed with DCM. The combined organic solution was concentrated. The residue was mixed with water, extracted with DCM (2*30 mL). The combined organic extractions were washed with brine, dried over anhydrous sodium sulfate, concentrated. The residue was separated by flash column chromatography on silica gel, eluting with 30-90% EtOAc/Hexane to afford 1.4612 g of product (yield: 72%). 1H-NMR (CDCl3): 8.803 (br, 1 H, NH), 7.300 (dt, J=9.0 Hz and 1.0 Hz, 1 H, Ar-H), 7.123 (dd, J=2.5 Hz and 1.0 Hz, 1 H, Ar-H), 7.078 (d, J=2.5 Hz, 1 H, Ar-H), 7.023 (dd, J=9.0 Hz and 2.5 Hz, 1 H, Ar-H), 4.391 (q, J=7.0 Hz, 2 H, CH2), 4.160 (m, 2 H, CH2), 3.881 (m, 2 H, CH2), 3.754-3.730 (m, 2 H, CH2), 3.702-3.624 (m, 8 H, 4 CH2), 3.545-3.527 (m, 2 H, CH2), 3.367 (s, 3 H, CH3), 1.403 (t, J=7.0 Hz, 3 H, CH3).
 

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