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Chemical Structure| 131088-00-1 Chemical Structure| 131088-00-1

Structure of 131088-00-1

Chemical Structure| 131088-00-1

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Product Details of [ 131088-00-1 ]

CAS No. :131088-00-1
Formula : C7H5ClO3
M.W : 172.57
SMILES Code : O=CC1=CC=C(O)C(Cl)=C1O
MDL No. :MFCD24674617

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Application In Synthesis of [ 131088-00-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 131088-00-1 ]

[ 131088-00-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 131088-00-1 ]
  • [ 76350-90-8 ]
  • 3-chloro-2-hydroxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzaldehyde [ No CAS ]
YieldReaction ConditionsOperation in experiment
491 mg With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20℃; Diisopropyl azodicarboxylate (0.758 mL, 3.82 mmol) in tetrahydrofuran (8.5 mL) was added dropwise to a cooled (0 C.) solution of 3-chloro-2,4-dihydroxybenzaldehyde (600 mg, 3.48 mmol), triphenylphosphine (1016 mg, 3.87 mmol) and 2-methyl-3-biphenylmethanol (758 mg, 3.82 mmol) in dry tetrahydrofuran (8.5 mL). The resulting reaction mixture was allowed to slowly warm to room temperature with stirring overnight. The crude product was purified by silica gel column chromatography employing 60% hexanes in dichloromethane (v/v) as eluent to yield 491 mg of the title compound as a colorless solid. 1H NMR (CHLOROFORM-d) delta: 11.80 (s, 1H), 9.77 (s, 1H), 7.47-7.50 (m, 2H), 7.42-7.46 (m, 2H), 7.35-7.40 (m, 1H), 7.31-7.34 (m, 2H), 7.28-7.31 (m, 2H), 6.78 (d, J=8.7 Hz, 1H), 5.30 (s, 2H), 2.28 (s, 3H).
 

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