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Chemical Structure| 131278-84-7 Chemical Structure| 131278-84-7

Structure of 131278-84-7

Chemical Structure| 131278-84-7

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Product Details of [ 131278-84-7 ]

CAS No. :131278-84-7
Formula : C13H23NO8
M.W : 321.32
SMILES Code : OC([C@H](O)[C@@H](O)C(O)=O)=O.CCOC([C@H]1C[C@@H](CCN1)C)=O

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Application In Synthesis of [ 131278-84-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 131278-84-7 ]

[ 131278-84-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 131278-84-7 ]
  • [ 74892-82-3 ]
YieldReaction ConditionsOperation in experiment
88% With potassium carbonate; In water; ethyl acetate; at 15 - 20℃; for 1h; 74 g of a mixture of ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate L-tartrate (13) and ethyl (2S,4S)-4-methyl-2-piperidinecarboxylate L-tartrate (14) (ratio 97/3), 370 ml of ethyl acetate and 75 ml of water are introduced in a reactor. Cooling is carried out at 15 C. and an aqueous solution (150 ml) of potassium carbonate (35 g) is added. The obtained biphasic solution is left under stirring at 20 C. for 1 hour, then the phases are separated, the aqueous phase is extracted once again using 150 ml of ethyl acetate, the two organic phases are concentrated by distillation at reduced pressure obtaining 36 g of ester, with a 96.05% potentiometric titre 96.05% then 34.4 g at 100%, with a 99.9% chemical purity. Molar yield: 88%. Ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate (9)/ethyl (2S,4S)-4-methyl-2-piperidinecarboxylate (10) (97.7/2.3) ratio.
 

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Similar Product of
[ 131278-84-7 ]

Chemical Structure| 74892-82-3

A606979 [74892-82-3]

(2R,4R)-Ethyl 4-methylpiperidine-2-carboxylate

Reason: Free-salt