Home Cart 0 Sign in  

[ CAS No. 1312937-40-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1312937-40-8
Chemical Structure| 1312937-40-8
Structure of 1312937-40-8 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 1312937-40-8 ]

Related Doc. of [ 1312937-40-8 ]

Alternatived Products of [ 1312937-40-8 ]

Product Details of [ 1312937-40-8 ]

CAS No. :1312937-40-8 MDL No. :MFCD24719811
Formula : C9H8N2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 192.17 Pubchem ID :-
Synonyms :

Safety of [ 1312937-40-8 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 1312937-40-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1312937-40-8 ]

[ 1312937-40-8 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 67-56-1 ]
  • [ 16064-15-6 ]
  • [ 1312937-40-8 ]
YieldReaction ConditionsOperation in experiment
79% In a 250 ml_ flask, a mixture of <strong>[16064-15-6]6,7-dihydroxyquinazolinone</strong> (15.00 g, 84.2 mmol) and DMF (1 .70 ml_, 21 .9 mmol, 0.26 eq.) in POCI3 (38.5 ml_, 421 mmol, 5 eq.) was stirred at 120 C for 3 h or until total dissolution of the solid is observed. POCI3 was distilled under vacuum and to the resulting foam was added toluene (50.0 ml_) and K2CO3 (1 1 .63 g, 84.2 mmol, 1 eq.). The mixture was cooled to 0 C and methanol (70.0 ml_) was added carefully slowly keeping the temperature under 40 C. The resulting suspension was stirred at room temperature for 45 min and the solvents were removed under vacuum to provide a solid foam. H2O (150 ml_) was added slowly and 50% NaOH (18 ml_) was added at 0 C to pH 5. The resulting solid was filtered and was washed with H2O (20 ml_) to give the title compound as a yellow solid (12.81 g, 79% yield). 1H NMR (d6-DMSO, ppm): delta 8.47 (s, 1 H), 7.27 (s, 1 H), 7.1 1 (s, 1 H), 4.02 (s, 3H).
79% Example 2: Preparation of 4-methoxyguinazoline-6,7-diol In a 250 mL flask, a mixture of <strong>[16064-15-6]6,7-dihydroxyquinazolinone</strong> (15.00 g, 84.2 mmol) and DMF (1.70 mL, 21.9 mmol, 0.26 eq.) in POCl3 (38.5 mL, 421 mmol, 5 eq.) was stirred at 120 C for 3 h or until total dissolution of the solid is observed. POCl3 was distilled under vacuum and to the resulting foam were added toluene (50.0 mL) and K2CO3 (11.63 g, 84.2 mmol, 1 eq.). The mixture was cooled to 0 C and methanol (70.0 mL) was added carefully slowly keeping the temperature under 40 C. The resulting suspension was stirred at room temperature for 45 min and the solvents were removed under vacuum to provide a solid foam. H2O (150 mL) was added slowly and 50% NaOH (18 mL) was added at 0 C to pH 5. The resulting solid was filtered and was washed with H2O (20 mL) to give the title compound as a yellow solid (12.81 g, 79% yield). 1H NMR (d6-DMSO, ppm): delta 8.47 (s, 1 H), 7.27 (s, 1 H), 7.11 (s, 1H), 4.02(s,3H)
  • 2
  • [ 1312937-40-8 ]
  • [ 183321-74-6 ]
Same Skeleton Products
Historical Records