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Chemical Structure| 1313758-49-4 Chemical Structure| 1313758-49-4

Structure of 1313758-49-4

Chemical Structure| 1313758-49-4

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Product Details of [ 1313758-49-4 ]

CAS No. :1313758-49-4
Formula : C10H11BN2O4
M.W : 234.02
SMILES Code : O=C(CN(C)C1)OB(C2=NC=CC=C2)OC1=O

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Application In Synthesis of [ 1313758-49-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1313758-49-4 ]

[ 1313758-49-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1313758-49-4 ]
  • [ 65202-50-8 ]
  • [ 67-63-0 ]
  • isopropyl 6-(pyridin-2-yl)pyridazine-3-carboxylate [ No CAS ]
  • 2
  • [ 1313758-49-4 ]
  • [ 65202-50-8 ]
  • isopropyl 6-(pyridin-2-yl)pyridazine-3-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With tris-(dibenzylideneacetone)dipalladium(0); 2-(dicyclohexylphoshphino)-2',4',6'-triisopropyl-1,1'-biphenyl; copper diacetate; potassium carbonate; In Isopropyl acetate; N,N-dimethyl-formamide; at 100℃; A series of additional analogues 14-17 was prepared using the methodology outlined in Scheme 2. Recently, 2-pyridyl N-methyliminodiacetic acid (MID A) boronate (10) has been reported as an air-stable slow-release reagent with high cross-coupling efficiency even with heteroaryl chlorides (Knapp et al, J. Am. Chem. Soc. 2009, 131, 6961). Therefore, this material was used in palladium-mediated cross-couple reactions with heteroaryl chlorides 11 - 13 to obtain 14 - 16, respectively. The ester 16 was then allowed to react with alkylamines in ethanol at 85 °C to generate amides 17. Scheme 2. Reagents and conditions: (a) Pd2(dba)3, XPhos, Cu(OAc)2, K2C03, DMF/IPA (4/1), 100 °C; (b) H2NR, ethanol, 85 °C (90percent).
 

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