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Chemical Structure| 1314886-98-0 Chemical Structure| 1314886-98-0

Structure of 1314886-98-0

Chemical Structure| 1314886-98-0

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Product Details of [ 1314886-98-0 ]

CAS No. :1314886-98-0
Formula : C15H18N2OS
M.W : 274.38
SMILES Code : NCC1(CCOCC1)C2=NC(C3=CC=CC=C3)=CS2
MDL No. :MFCD31559625

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Application In Synthesis of [ 1314886-98-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1314886-98-0 ]

[ 1314886-98-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1092400-82-2 ]
  • [ 1314886-98-0 ]
  • N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
62% With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃; for 8h; A mixture of <strong>[1092400-82-2]3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid</strong> (52mg, 0.202mmole), (4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methanamine (50mg, 0.184mmole), and EDCI (38.5mg, 0.202mmole) in CH2Cl2 (2ml) was stirred at room temperature for 8 h. The reaction mixture was then diluted with methylene chloride (10 ml), washed with water (5 ml), dried over MgSO4 and concentrated under reduced pressure. The residue was purified by ISCO (silica gel, elute: 2% methanol in CH2Cl2) to give N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide as a white solid product (59mg, 62% yield): 1H NMR (CDCl3, 500MHz ): 8.49(s, 1H), 8.22 (d, J=7.5Hz, 1H), 7.98 (d, J=8.5Hz, 1H), 7.88 (d, J=8Hz, 2H), 7.56-7.53(m, 2H), 7.52 (s, 1 H), 7.369-7.31 (m, 3H), 3.97-3.93 (m, 2H), 3.91 (d, J=5.5Hz, 2H), 3.77-3.74 (m, 2H), 2.36-2.28 (m, 2H), 2.06-2.04 (m, 2H). MS (ESI) m/z: Calculated for C25H21F3N4O3S: 514.13; found: 515.1 (M+H)+.
 

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