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Chemical Structure| 1314922-47-8 Chemical Structure| 1314922-47-8

Structure of 1314922-47-8

Chemical Structure| 1314922-47-8

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Product Details of [ 1314922-47-8 ]

CAS No. :1314922-47-8
Formula : C7H7N3O
M.W : 149.15
SMILES Code : OC1=C2C(NC=C2)=NC(C)=N1
MDL No. :MFCD04120036

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Application In Synthesis of [ 1314922-47-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1314922-47-8 ]

[ 1314922-47-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 52133-67-2 ]
  • [ 124-42-5 ]
  • [ 1314922-47-8 ]
YieldReaction ConditionsOperation in experiment
2-Methyl-4-hydroxypyrrolo[2,3-d]pyrimidine (3).; Acetamidine hydrochloride (2, 0.05 mol, 4.7 g) was added to the 0.1 M sodium ethoxide solution (75 ml) and kept stirring under room temperature for 0.5 h. After removing the formed sodium chloride by filtration, the filtrate was added the ethyl alpha-cyano-gamma,gamma-diethoxybutyrate (1, 0.05 mol, 11.5 g) and the solution was heated under reflux for 5 h. After the removal of most solvent under vacuum, acetic acid was added to adjust the pH to 7.0 and 10.8 g precipitation as white powder. Ethanol (110 ml) with concentrated sulfuric acid (2 ml) was added to the collected powder and was refluxed for 2 h. By the end of the reaction an equal volume of water was added and kept at 4° C. overnight. The pyrrolopyrimidine 3 precipitated as white powder (2.1 g) was used for next step without further purification.
 

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