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Chemical Structure| 1318758-14-3 Chemical Structure| 1318758-14-3

Structure of 1318758-14-3

Chemical Structure| 1318758-14-3

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Product Details of [ 1318758-14-3 ]

CAS No. :1318758-14-3
Formula : C9H14N2O2S
M.W : 214.29
SMILES Code : O=C(OC(C)(C)C)NC1=C(C)N=CS1
MDL No. :MFCD22375371

Safety of [ 1318758-14-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 1318758-14-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1318758-14-3 ]

[ 1318758-14-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 20485-41-0 ]
  • [ 75-65-0 ]
  • [ 1318758-14-3 ]
YieldReaction ConditionsOperation in experiment
78% With diphenyl phosphoryl azide; triethylamine; at 95℃; for 1.5h; To a solution of <strong>[20485-41-0]4-methyl-1,3-thiazole-5-carboxylic acid</strong> (5.0 g, 34.9 mmol) in tert-butyl alcohol (125 mL) were successively added triethylamine (14.6 mL, 105 mmol) and DPPA (15.1 mL, 69.9 mmol) at room temperature, and the mixture was stirred at 95°C for 1.5 hr. The reaction mixture was cooled to room temperature, saturated aqueous sodium hydrogen carbonate solution was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography [eluent: hexane-ethyl acetate (2:1-1:3)] to give the title compound (2.34 g) as pale-yellow crystals (yield 78percent). 1H NMR (300 MHz, DMSO-d6) delta 1.47 (9H, s), 2.26 (3H, s), 8.55 (1H, s), 9.73 (1H, brs).
 

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