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[ CAS No. 1321518-05-1 ]

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2D
Chemical Structure| 1321518-05-1
Chemical Structure| 1321518-05-1
Structure of 1321518-05-1 *Storage: {[proInfo.prStorage]}

Quality Control of [ 1321518-05-1 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 1321518-05-1 ]

SDS

Product Details of [ 1321518-05-1 ]

CAS No. :1321518-05-1MDL No. :MFCD11878172
Formula : C13H21BN2O2 Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :248.13Pubchem ID :45786011
Synonyms :

Computed Properties of [ 1321518-05-1 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 1321518-05-1 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P280-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1321518-05-1 ]

  • Downstream synthetic route of [ 1321518-05-1 ]

[ 1321518-05-1 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 1321518-05-1 ]
  • C15H9(18)FN4 [ No CAS ]
  • 2
  • [ 1321518-05-1 ]
  • C37H32N5(1+)*C2F3O2(1-) [ No CAS ]
  • 3
  • [ 1321518-05-1 ]
  • C36H29N5*CHF3O3S [ No CAS ]
  • C35H27N5*CHF3O3S [ No CAS ]
  • 4
  • [ 1321518-05-1 ]
  • ethyl 1-bromo-5-chloro-6-methylimidazo[1,5-a]pyridine-7-carboxylate [ No CAS ]
  • ethyl 5-chloro-1-(2-(dimethylamino)pyridin-4-yl)-6-methylimidazo[1,5-a]pyridine-7-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
38% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In N,N-dimethyl-formamide; toluene; at 100.0℃;Inert atmosphere; : in a nitrogen-protected 50 mL single-necked flask, ethyl 1-bromo-5-chloro-6-methylimidazo[1,5-a]pyridine-7-carboxylate (504 mg, 1.59 mmol), <strong>[1321518-05-1]N,N-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)pyridin-2-amine</strong> (396 mg, 1.59 mmol), Pd(dppf)Cl2 (58 mg, 0.08 mmol), Cs2CO3 (1.04 g, 3.19 mmol) were added into 6 mL of toluene:DMF=3:1. The flask was exchanged for three times with nitrogen and the mixture was stirred in an oil bath at 100 C. overnight. The mixture was extracted with ethyl acetate (100 mL) and washed with water (50 mL*2) and saturated brine (50 mL). The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated to provide a crude product. After purified by column chromatography (petroleum ether:EtOAc=5:1), white solids (217 mg, yield: 38%) were obtained. MS (ESI) m/z 359 [M+H]+.
  • 5
  • [ 1321518-05-1 ]
  • C18H18N5(1+)*CF3O3S(1-) [ No CAS ]
  • 6
  • [ 1321518-05-1 ]
  • 2-bromo-5-isopropyloxazole [ No CAS ]
  • C13H17N3O [ No CAS ]
  • 7
  • [ 1321518-05-1 ]
  • 5-bromo-2-(tert-butyl)oxazole [ No CAS ]
  • C14H19N3O [ No CAS ]
  • 8
  • [ 1321518-05-1 ]
  • [ 333-27-7 ]
  • C14H24BN2O2(1+)*CF3O3S(1-) [ No CAS ]
YieldReaction ConditionsOperation in experiment
In dichloromethane; at 20.0℃; for 4.0h; Commercially available N,N-dimethyl-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyridin- 2-amine (0.25 g, 1 mmol) was dissolved in dichloromethane (5 ml_). To the resultant stirring solution was added dropwise at room temperature methyl trifluoromethanesulfonate (0.124 mL, 1.1 mmol). The solution was stirred at room temperature for 4 hours. The reaction mixture was concentrated to remove dichloromethane and the residue was dried in vacuo to obtain a yellow glass/foam, which was directly used for the next step.
In dichloromethane; at 20.0℃; for 4.0h; Commercially available N,N-dimethyl-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyridin- 2 -amine (0.25 g, 1 mmol) was dissolved in dichloromethane (5 ml_). To the resultant stirring solution was added dropwise at room temperature methyl trifluoromethanesulfonate (0.124 mL, 1.1 mmol). The solution was stirred at room temperature for 4 hours. The reaction mixture was concentrated to remove dichloromethane and the residue was dried in vacuo to obtain a yellow glass/foam, which was directly used for the next step.
In dichloromethane; at 20.0℃; for 4.0h; Commercially available N,N-dimethyl-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyridin- 2-amine (0.25 g, 1 mmol) was dissolved in dichloromethane (5 mL). To the resultant stirring solution was added dropwise at room temperature methyl trifluoromethanesulfonate (0.124 mL, 1.1 mmol). The solution was stirred at room temperature for 4 hours. The reaction mixture was concentrated to remove dichloromethane and the residue was dried in vacuo to obtain a yellow glass/foam, which was directly used for the next step.
  • 9
  • [ 1321518-05-1 ]
  • ACI-3613 [ No CAS ]
Historical Records

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[ 1321518-05-1 ]

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Amines

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Related Parent Nucleus of
[ 1321518-05-1 ]

Pyridines

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