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Chemical Structure| 132470-83-8 Chemical Structure| 132470-83-8

Structure of 132470-83-8

Chemical Structure| 132470-83-8

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Product Details of [ 132470-83-8 ]

CAS No. :132470-83-8
Formula : C7H4F3NO
M.W : 175.11
SMILES Code : O=CC1=NC=CC(C(F)(F)F)=C1
MDL No. :MFCD11848102
InChI Key :FKNSTSIMTSEJOD-UHFFFAOYSA-N
Pubchem ID :14761471

Safety of [ 132470-83-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P280

Application In Synthesis of [ 132470-83-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 132470-83-8 ]

[ 132470-83-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 68-12-2 ]
  • [ 175205-81-9 ]
  • [ 132470-83-8 ]
YieldReaction ConditionsOperation in experiment
To a solution of <strong>[175205-81-9]2-bromo-4-(trifluoromethyl)pyridine</strong> (1 .5 g, 6.64 mmol) in dry toluene (20 mL), was added n-butyllithium (3.3 mL, 8.30 mmol, 2.5 M) dropwise under nitrogen. After the addition, the reaction was stirred at -78 C for 10 minutes and A/,A/-dimethylformamide (0.77 mL, 9.95 mmol) was added dropwise at -78 C and stirred for 10 minutes at -78 before sodium borohydride (0.5 g, 13.3 mmol) and methanol (3.75 mL) were added. The reaction was warmed to room temperature and stirred for 1 h. The reaction was quenched with aqueous ammonium chloride solution and extracted with ethyl acetate (30 mL x 2). The combined organic phases were washed with brine (30 mL), dried over sodium sulfate, filtered and concentrated to give (4-(trifluoromethyl)pyridin-2-yl)methanol (1 .1 g, 6.21 mmol, 94%) as a white solid.
 

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