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CAS No. : | 1325694-78-7 | MDL No. : | |
Formula : | C12H10BrClN2O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | KLFCDTDRDRISSC-UHFFFAOYSA-N |
M.W : | 329.58 | Pubchem ID : | 84819521 |
Synonyms : |
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Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
33% | With potassium <i>tert</i>-butylate In tetrahydrofuran at 50℃; for 16 h; Inert atmosphere | General procedure: To a mixture of dichloride 21 (0.625 g, 2.7 mmol) and potassium tert-butoxide (0.395 g, 4.1 mmol) was added a solution of para-methoxybenzyl alcohol (0.568 g, 4.1 mmol) in THF (8 mL). Reaction mixture was heated to 50 °C overnight. Reaction mixture was filtered and concentrated under reduced pressure. Product was purified via automated chromatography (EtOAc: Hexanes, 20:80) to provide 22 as a clear oil in 33percent yield. 1H NMR (400 MHz, CDCl3) δ 8.38 (s, 1H), 7.30 (d, J = 8.6 Hz, 1H), 6.83 (d, J = 8.6 Hz, 1H), 5.38 (s, 2H), 3.73 (s, 3H). 13C NMR (101 MHz, CDCl3) δ 166.68, 160.23, 159.85, 155.22, 130.28, 130.16, 130.00, 127.24, 114.02, 106.27, 70.10, 55.32. |