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Chemical Structure| 1329166-77-9 Chemical Structure| 1329166-77-9

Structure of 1329166-77-9

Chemical Structure| 1329166-77-9

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Product Details of [ 1329166-77-9 ]

CAS No. :1329166-77-9
Formula : C9H6ClN3O
M.W : 207.62
SMILES Code : O=CC1=CC(Cl)=CC=C1N2N=CN=C2
MDL No. :MFCD28676004

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Application In Synthesis of [ 1329166-77-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1329166-77-9 ]

[ 1329166-77-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1329166-77-9 ]
  • [ 62327-21-3 ]
  • [ 1329166-78-0 ]
YieldReaction ConditionsOperation in experiment
26% To a suspension of NaH (60percent, 0.100 g, 2.495 mmol) in THF (4 mL) was added dropwise tert-butyl 2-(dimethoxyphosphoryl)acetate (0.530 mL, 2.67 mmol). The cloudy reaction mixture was stirred at RT for 45 min and then cooled to 0 °C. Next a solution of Intermediate 20A (0.37 g, 1.78 mmol) in THF (14 mL) was added. The reaction mixture turned orange. After 30 min, the reaction was quenched with saturated NH4CI and then the reaction was diluted with EtOAc and water. The layers were separated and the organic layer was washed with brine, dried over Na2S04, filtered and concentrated. Purification by normal phase chromatography afforded 0.178 g (26 percent) of Intermediate 20B, as a yellow gum. MS (ESI) m/z: 306.3 (M+H)+. NMR (400 MHz, CDC13) delta ppm 1.49 (s, 9 H), 6.38 (d, J=15.9 Hz, 1 H), 7.34 - 7.42 (m, 2 H), 7.48 (dd,J=8.3, 2.2 Hz, 1 H), 7.73 (d, J=2.2 Hz, 1 H), 8.17 (s, 1 H), 8.29 (s, 1 H).
 

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