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Chemical Structure| 133243-99-9 Chemical Structure| 133243-99-9

Structure of 133243-99-9

Chemical Structure| 133243-99-9

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Product Details of [ 133243-99-9 ]

CAS No. :133243-99-9
Formula : C12H15NO2
M.W : 205.25
SMILES Code : O=CC1CN(CC2=CC=CC=C2)CCO1

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  • Downstream synthetic route of [ 133243-99-9 ]

[ 133243-99-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 40987-24-4 ]
  • [ 133243-99-9 ]
YieldReaction ConditionsOperation in experiment
(4-Benzylmorpholin-2-yl)methanol (200 mg) and Dess-Martin periodinane (409 mg) are stirred for 2 hours in CH2Cl2 (15 ml). Satd. aqueous NaHCOs (50 ml) is added and the mixture stirred for 45 min. The layers are separated, dried (Na2SO4), filtered, and the solvent is removed under reduced pressure. Sodium triacetoxyborohydride (448 mg) is added to a mixture of tert-butyl piperazine-1-carboxylate (150 mg), 4-benzylmorpholine-2-carbaldehyde (220 mg) and acetic acid (111 mul) in THF (10 ml). The mixture is stirred over night. An aqueous solution of potassium carbonate (15%) is added and the mixture stirred for 30 min. The organic layer is separated and the aqueous layer is extracted with CH2Cl2. The combined organic layers are washed with an aqueous solution of potassium carbonate (20%), dried (Na2SO4) and filtered, and the solvent is removed under reduced pressure to give tert-butyl 4- ((4-benzylmorpholin-2-yl)methyl)piperazine-l-carboxylate (165 mg).
 

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