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CAS No. : | 13391-35-0 | MDL No. : | MFCD00059326 |
Formula : | C10H12O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 164.20 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With potassium carbonate In butanone for 12h; Heating; | |
100% | With potassium carbonate In acetone at 20℃; Reflux; | |
99% | With potassium carbonate In acetone Reflux; |
98% | With potassium carbonate In acetone Heating; | |
97% | With potassium carbonate In acetone at 65℃; for 16h; | |
96% | With potassium carbonate In acetone Heating; | |
95% | With potassium hydroxide; dimethyl sulfoxide at 20℃; for 1h; | |
95% | With potassium carbonate In acetone for 12h; Heating; | |
95% | Stage #1: 4-methoxy-phenol With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Stage #2: allyl bromide In tetrahydrofuran for 4h; Heating; | |
95% | With potassium carbonate In acetone for 4h; Heating; | |
95% | With potassium carbonate In acetone Heating; | |
93% | With potassium carbonate In acetone at 75℃; for 5h; Microwave irradiation; Continuous-flow; | |
92% | With potassium carbonate In acetone Reflux; | |
92% | Stage #1: 4-methoxy-phenol With sodium hydroxide In N,N-dimethyl-formamide at 50℃; for 0.5h; Stage #2: allyl bromide In N,N-dimethyl-formamide at 60℃; for 2h; | |
91% | With sodium hydride In tetrahydrofuran Heating; | |
91% | With potassium carbonate In acetone for 12h; Reflux; | General Procedure for the Preparation of Aryl Allyl Ethers (1a-1k, 1m, 1r-1t) General procedure: To a stirred suspension of potassium carbonate (3.46 g, 25.00 mmol, 2.50 equiv.) in acetone (40.0mL) were added allyl bromide (2.42 g, 20.00 mmol, 2.00 equiv.) and the corresponding phenol(10.00 mmol, 1.00 equiv.) at room temperature, and stirring was continued for 12 h under refluxcondition. The reaction was monitored by TLC. After complete conversion of the phenol, thereaction mixture was filtrated using Celite followed by concentration. The crude product was furtherpurified by flash column chromatography to obtain the desired aryl allyl ethers (Petroleum etherand EtOAc). |
90% | With potassium carbonate In acetone for 8h; Heating; | |
89% | With potassium carbonate In acetone Heating; | |
89% | With potassium carbonate In acetone for 16h; Reflux; Inert atmosphere; Schlenk technique; | Synthesis of 1-allyloxy-4-methoxybenzene ether (3) Allyl bromide (3.0 mL, 32.0 mmol) and K2CO3 (9.0 g, 64.0 mmol) were added to a solution of 4-methoxyphenol (4.0 g, 32.0 mmol) in 70mL of acetone in a 250 mL round bottom flask and refluxed for 16 h. After filtration, solvent was removed under reduced pressure. The residue was dissolved in 50 mL of DCM and washed sequentially with (15 mL) 1.0 M NaOH, water and brine solution. The organic layer was dried over anhydrous MgSO4 and removal of solvent under reduced pressure afforded a white coloured solid. NMR data (1H, 13C) obtained is essentially the same as reported in literature [29]. Yield=4.7 g (89%). 1H NMR (400 MHz, CDCl3, δ): 6.82-6.88 (m, 4H, C6H4), 6.06 (m, 1H,=CH), 5.41 (dq, 1H, cis-CH, 1J=17Hz), 5.28 (dq, 1H, trans-CH, 1J=10.5Hz, 2J=3J=1.5Hz), 4.49 (dd, 2H, -OCH2, 1J=5.3Hz, 2J=3J=1.5Hz), 3.77 (s, 3H, -OCH3) ppm; 13C NMR (100MHz, CDCl3, δ): 153.9 (p-C6H4O), 152.8 (i-C6H4O), 133.6 (=CH), 117.5 (=CH2), 115.8 (o-C6H4), 114.6 (m-C6H4), 69.6 (-OCH2), 55.7 (-OCH3) ppm. |
88% | With caesium carbonate In acetonitrile for 5h; Heating; | |
88% | With potassium carbonate In acetone for 12h; Reflux; | |
87% | With potassium carbonate In acetone for 2h; Heating; | |
86% | With potassium carbonate In acetonitrile for 3h; Heating; | |
86% | Stage #1: 4-methoxy-phenol; allyl bromide With potassium carbonate In acetonitrile at 20℃; Reflux; Stage #2: With sodium hydroxide In diethyl ether | 13.a To a stirred solution of 4-methoxyphenol (13.1 ) (50g, 402.8mmol) in acetonitrile (500ml_) were added K2C03 (61 .23g, 443mmol) and allyl bromide (38.34mL, 443mmol) at room temperature, and stirring was continued for 4h under reflux. After cooling to rt, filtration of the reaction mixture followed by concentration, the residue was partitioned between water (200ml_) and ether (3x300ml_). Combined ether layers were washed with a solution of 2M NaOH (1 x250ml_), water (1 x200 ml_), brine (1 x200ml_) and dried over Na2S04 and concentrated to afford the title product (13.2) as yellow oil (86%). |
83% | Stage #1: 4-methoxy-phenol With sodium hydride In tetrahydrofuran at 0℃; for 0.25h; Stage #2: allyl bromide In tetrahydrofuran at 40℃; | |
79% | With potassium carbonate In acetonitrile at 80℃; for 12h; | |
78% | With potassium carbonate In water for 5h; Reflux; | |
75% | With potassium carbonate In acetone Reflux; | General procedure A for preparation of allyl protected substrates 1 General procedure: To a solution of the alcohol/amine (1eq.) in acetone (0.8M) was added anhydrous K2CO3 (1.2eq.) followed by allyl bromide (1.5 eq.). The mixture was heated at reflux over night. After cooling to room temperature, the reaction mixture was filtered, concentrated, redissolved in DCM (or ethylacetate), washed with 1M aq. NaOH and then dried over MgSO4 and concentrated in vacuo. Purification by column chromatography (EtOAc/hexanes) gave the title product. |
65% | With potassium carbonate In acetone Reflux; | Aryl allyl ethers (2-2g). General procedure[11]. General procedure: A slurry of 6 mmol of an appropriate phenol 3-3g, 0.8 g (6.6 mmol) of allyl bromide, and 0.91 g (6.6 mmol) of crushed calcined K2CO3 in 10 mL of anhydrous acetone was boiled at stirring for 10-12 h. The reaction was monitored by TLC (Rf of reaction products ~0.7, eluent hexane-EtOAc, 9 : 1). Then the reaction mixture was diluted with water (30 mL), the reaction products were extracted with Et2O (3 × 40 mL). The combined extracts were washed with 1 M water solution of NaOH (15 mL) and dried with MgSO4. The solvent was removed at a reduced pressure. The obtained lowmelting crystals 2b, 2c, and 2g or oily substances 2and 2d-2f were purified by column chromatography on silica gel, eluent hexane-EtOAc, 9 : 1-8 : 2. |
47% | With potassium carbonate In acetone for 10h; Heating; | |
With potassium carbonate; acetone | ||
With potassium carbonate In acetone | ||
With potassium carbonate In acetone Heating; | ||
With potassium carbonate | ||
With potassium hydroxide 1.) DMSO, 5 min, 2.) DMSO, RT, 3 h; Yield given. Multistep reaction; | ||
With tetra-(n-butyl)ammonium iodide; potassium carbonate In acetone for 12h; Heating; | ||
With potassium carbonate In acetone for 12h; Heating; | ||
With potassium carbonate; potassium iodide In acetone at 20℃; for 10h; | ||
With potassium carbonate In acetone Reflux; | General procedure for O-benzylation andO-allylation General procedure: To a suspension of phenol (1.0 equiv) and K2CO3(2.5 equiv) in acetone (10 mL), benzylbromideor allylbromide (1.05 equiv) was added, and refluxed for 7-15 h. Aftercompletion of the reaction, the suspension was filtered. The filtrate wasevaporated to dryness, quenched with water and extracted twice with ethylacetate. The organic layer thus obtained was washed with brine, dried overanhydrous Na2SO4 and evaporated to get the crude productwhich was purified by column chromatography on silica gel (60-120 mesh) usingethyl acetate-hexane mixture as eluent to afford the pure product | |
With potassium carbonate In acetone at 60℃; Inert atmosphere; | ||
With potassium carbonate In water; acetonitrile | 44.a Step (a): Step (a): 1-(allyloxy)-4-methoxybenzene (13.2) To a stirred solution of 4-methoxyphenol (13.1) (50 g, 402.8 mmol) in acetonitrile (500 mL) were added K2CO3 (61.23 g, 443 mmol) and allyl bromide (38.34 mL, 443 mmol) at room temperature, and stirring was continued for 4 h under reflux. After cooling to rt, filtration of the reaction mixture followed by concentration, the residue was partitioned between water (200 mL) and ether (3*300 mL). Combined ether layers were washed with a solution of 2M NaOH (1*250 mL), water (1*200 mL), brine (1*200 mL) and dried over Na2SO4 and concentrated to afford the title product (13.2) as yellow oil (86%). | |
With potassium carbonate In acetone at 66℃; for 12h; | ||
With potassium carbonate In acetone for 3.5h; Inert atmosphere; Reflux; | ||
With potassium carbonate In acetone at 65℃; Inert atmosphere; | ||
In acetone for 72h; Reflux; | ||
With potassium carbonate In acetone for 7.5h; Reflux; | 4-Methoxy-2-(2-propenyl) phenol (4c) To a solutionof 4b (6.2 g, 50 mmol) in acetone (30 mL) potassiumcarbonate (7.6 g, 66 mmol) and allyl bromide (5.4 mL,62 mmol) were added, and the mixture was stirred underreflux for 7.5 h. After cooling, the organic materials wereextracted with Et2O. The organic layer was washed withNaOH (aq.) and brine, dried over anhydrous Na2SO4,and concentrated in vacuo; NMR (500 MHz): δH 3.77(3H, s, OCH3), 4.49 (2H, ddd, J = 5.5, 1.4, 1.4 Hz, H-1′),5.28 (1H, ddd, J = 10.6, 2.8, 1.4 Hz, H-3′), 5.41 (1H,ddd, J = 17.4, 3.3, 1.7 Hz, H-3′), 6.06 (1H, m, H-2′), 6.86(4H, m, H-2,3,5,6). Its 1H NMR spectra was identicalwith that reported previously.13)To the above-mentioned crude material (260 mg) wasadded dibutylhydroxytoluene (BHT, 36 mg, 0.16mmol), and the mixture was stirred under reflux at190 °C (bath temperature) for 7.5 h. After cooling, themixture was purified by silica gel column chromatography(18 mL) with hexane/EtOAc (40:1) to afford 4c(210 mg, 1.3 mmol, 77%) as yellow oil; NMR (500MHz): δH 3.38 (2H, d, J = 6.3 Hz, H-1′), 3.76 (3H, s,OCH3), 4.59 (1H, s, OH), 5.16 (1H, dd, J = 17.6, 1.5Hz, H-3′), 5.16 (1H, dd, J = 9.7, 1.5 Hz, H-3′), 6.01(1H, ddt, J = 17.6, 9.7, 6.3 Hz, H-2′), 6.72 (3H, m,H-3,5,6). Its 1H NMR spectra was identical with thatreported previously.13) This was employed for the nextstep without further purification. | |
With potassium carbonate In acetone at 66℃; for 12h; | ||
With potassium carbonate In acetone at 65℃; for 16h; | ||
With potassium carbonate In acetone at 66℃; for 12h; | ||
With potassium carbonate In acetone at 60℃; for 4h; Sonication; | ||
With potassium carbonate In acetone at 60℃; | ||
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 16h; | ||
With potassium carbonate In acetone for 8h; Reflux; | ||
With potassium carbonate In acetone Reflux; | ||
With potassium carbonate In acetone Reflux; | ||
With potassium carbonate In acetone at 20 - 65℃; for 12h; Inert atmosphere; | 7.1 Step 1: Synthesis of intermediate WX007-2 At room temperature under nitrogen atmosphere, compound WX007-1 (30.00 g, 241.67 mmol) and allyl bromide (35.08 g, 290.00 mmol) were dissolved in acetone (300 mL), and potassium carbonate (66.80 g, 483.34 mmol) was added; and the reaction mixture was heated to 65 °C and stirred and reacted at 65 °C for 12 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and filtered, and the filter cake was discarded, the solvent was removed from the filtrate under reduced pressure. The resulting residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate =1/0-100/1, volume ratio) to obtain intermediate WX007-2. MS-ESI m/z: 165.0 [M+H]+. 1H NMR (400 MHz, CDCl3) δ: 6.92-6.78 (m, 4H), 6.13-6.00 (m, 1H), 5.41 (dq, J=1.6, 17.2 Hz, 1H), 5.28 (dq, J=1.4, 10.2 Hz, 1H), 4.51 (t, J=1.6 Hz, 1H), 4.50 (t, J=1.4 Hz, 1H), 3.78 (s, 3H). | |
With potassium carbonate In acetone at 65℃; for 12h; Inert atmosphere; | 5.1 Step 1: Synthesis of intermediate WX005-2 At room temperature and under nitrogen atmosphere, the compound WX005-1 (30.00 g, 241.67 mmol) and 3-bromoprop-1-ene (35.08 g, 290.00 mmol) were dissolved in acetone (300 mL), potassium carbonate (66.80 g, 483.34mmol) was added, and the reaction mixture was heated to 65 °C and stirred and reacted for 12 hours. After completionof the reaction, the reaction mixture was cooled to room temperature and filtered, and the filter cake was discarded, the solvent was removed from the filtrate under reduced pressure. The resulting residue was purified by column chromatography(eluent: petroleum ether/ethyl acetate = 1/0-100/1, volume ratio) to obtain the intermediate WX005-2. MS-ESIm/z: 165.0 [M+H]+. 1H NMR (400 MHz, CDCl3) δ: 6.92-6.78 (m, 4H), 6.13-6.00 (m, 1H), 5.41 (dq, J = 1.6, 17.2 Hz, 1H),5.28 (dq, J = 1.4, 10.2 Hz, 1H), 4.51 (t, J = 1.6 Hz, 1H), 4.50 (t, J = 1.4 Hz, 1H), 3.78 (s, 3H). | |
With potassium carbonate In acetone at 60℃; for 12h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With 3-chloro-benzenecarboperoxoic acid In dichloromethane for 20h; Ambient temperature; | |
69% | With dihydrogen peroxide In methanol; water; acetonitrile at 40℃; for 90h; chemoselective reaction; | |
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 45℃; for 48h; |
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With aminomethyl resin-supported N-propylbarbituric acid In tetrahydrofuran at 70℃; | |
96% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In methanol at 20℃; for 12h; | |
96% | Stage #1: allyl (4-methoxyphenyl) ether With bis(1,5-cyclooctadiene)nickel (0); diphenylsilane; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl-formamide at 20℃; for 8h; Schlenk technique; Inert atmosphere; Sealed tube; Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide at 50℃; for 2h; Schlenk technique; Inert atmosphere; Sealed tube; | 3.1 General Procedure of the Deallylation Reaction General procedure: A dried 25 mL Schlenk tube containing a magnetic stir bar was charged with Ni(COD)2 (5.5 mg,0.02 mmol, 1.0 mol%) and 4,4'-di-tert-butyl-2,2'-bipyridine (L3d) (5.4 mg, 0.02 mmol, 1.0 mol%),and DMF (5.0 mL) under a N2 atmosphere. Then the tube was sealed with a rubber stopper andstirred for 5 min. The mixture of aryl allyl ether (1, 2.00 mmol, 1.00 equiv.) and Ph2SiH2 (2a, 442.4mg, 2.40 mmol, 1.20 equiv.) or TMDS (2b, 332.4 mg, 2.40 mmol, 1.20 equiv.) was added into thetube within 15 seconds. The mixture was further stirred at room temperature for 4 h. The reactionwas monitored by TLC. The reaction time can be extended appropriately (up to 8 h) to make thecomplete conversion of 1 as far as possible. After complete conversion of the aryl allyl ether 1, 6 MHCl (1.0 mL) was added into the tube to quench the reaction. After stirring at 50 oC for another 2 h,mL water (15.0) and ethyl acetate (5.0 mL) were added to the system. The aqueous phase was thenextracted with ethyl acetate (5.0 mL × 3). The combined organic phase was dried over Na2SO4,filtrated, and concentrated in vacuum. The crude product was purified through flash columnchromatography (Petroleum ether and EtOAc). |
93% | With magnesium; lithium tert-butoxide In tetrahydrofuran at 20℃; for 12h; | |
93% | With palladium diacetate; sodium hydride In N,N-dimethyl acetamide; mineral oil at 50℃; for 3h; Inert atmosphere; | 11 Under nitrogen protection,Palladium acetate (0.018 mmol, 6 mol%)And sodium hydride (60% in oil, 0.51 mmol, 1.7 equiv)Suspended in DMA (1.0 mL),Stir at 25 ° C for 5 minutes.Add compound 8 (0.3 mmol)In DMA (0.5 mL) solution,Then react at 50 ° C for 3 hours,Add ice water to stop the reaction,Adjust the pH to 3.5 with dilute hydrochloric acid,Extracted with ethyl acetate,Combine the extracts,Dry with sodium sulfate,Rotary and steamed,Purified by column chromatography,Product 9 was obtained in a yield of 93%. |
90% | With diisobutylaluminium hydride In diethyl ether; toluene 1.) 0 deg C, 5 min, 2.) r.t., 2 h; | |
90% | With sodium tetrahydroborate; lithium chloride In tetrahydrofuran at 0 - 35℃; | |
90% | With sodium tetrahydroborate; nickel(II) chloride hexahydrate In methanol at 0℃; | General procedure for O-debenzylation orO-deallylation of phenols General procedure: To a solution of benzyloxybenzene (1.0 equiv.) and NiCl2.6H2O(1.5 equiv.) in methanol (5 mL) at 0 oC, NaBH4 (3.0equiv.) was added and stirred until complete consumption of the startingmaterial. The progress of the reaction was monitored by TLC. After completion,the reaction mixture was quenched with methanol and stirred for another 20 min.It was then filtered through celite-545 pad and the filtrate wasconcentrated under reduced pressure. The crude product, thus obtained, waspurified by column chromatography on activated silica gel (60-120 mesh) using ethylacetate-hexane mixture as eluent to afford the pure phenol. Compounds 2(a-g)were characterized by comparing with authentic samples. |
83% | With titanium(III) chloride; magnesium In tetrahydrofuran for 2h; Heating; | |
83% | With palladium diacetate; sodium hydride In N,N-dimethyl acetamide at 20℃; for 4h; Inert atmosphere; | |
78% | With 1-methyl-pyrrolidin-2-one; potassium carbonate; 2-amino-benzenethiol for 0.25h; Heating; | |
76% | With sodium acetate; nickel In N,N-dimethyl-formamide for 18h; Ambient temperature; | |
68% | With potassium <i>tert</i>-butylate; diphenylphosphane In N,N-dimethyl-formamide at 70℃; for 12h; Sealed tube; | |
96 %Chromat. | With C20H32Cl4Ru2; water In water at 110℃; for 11h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: allyl (4-methoxyphenyl) ether With sec.-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Stage #2: (+)-B-methoxydiisocamphenylborane In tetrahydrofuran at -78℃; for 1h; Stage #3: With boron trifluoride diethyl etherate In tetrahydrofuran at -78℃; for 0.0833333h; Further stages.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 17 % Spectr. 2: 20 % Spectr. 3: 4 % Spectr. 4: 20 % Spectr. | With potassium hydroxide In methanol at 20℃; for 96h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With ammonium bromide; acetic acid In tetrahydrofuran; water at 20℃; for 3h; Electrochemical reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
64% | With iron(III) chloride; lithium aluminium tetrahydride; hydrogen In tetrahydrofuran at 18℃; for 20h; Inert atmosphere; Sealed tube; |
Tags: 13391-35-0 synthesis path| 13391-35-0 SDS| 13391-35-0 COA| 13391-35-0 purity| 13391-35-0 application| 13391-35-0 NMR| 13391-35-0 COA| 13391-35-0 structure
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P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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