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Chemical Structure| 1341156-62-4 Chemical Structure| 1341156-62-4
Chemical Structure| 1341156-62-4

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CAS No. :1341156-62-4
Formula : C11H18O5
M.W : 230.26
SMILES Code : C#CCOCCOCCOCCOCC=O
MDL No. :N/A

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Application In Synthesis

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1341156-62-4 ]

[ 1341156-62-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 474645-27-7 ]
  • [ 1341156-62-4 ]
  • C50H85N5O11 [ No CAS ]
YieldReaction ConditionsOperation in experiment
10 mg With sodium cyanoborohydride; acetic acid; In dichloromethane; at 20℃; for 2h; To a solution of compound 24 (920 mg, 3.96 mmol) in 70 mL of dichloromethane was added Dess-Martin Periodinane (2.25 g, 5.30 mmol). The reaction mixture was stirred at ambient temperature overnight. The reaction was quenched with the solution of sodium bisulfite in 60 mL of saturated sodium bicarbonate. The mixture was separated. The organic layer was washed with saturated sodium bicarbonate, brine, dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by flash column chromatography to give compound (0.54 g, 2.345 mmole); 1H NMR (400 MHz, CDCl3) 9.69 (s, 1H), 4.16-4.13 (m, 2H), 3.71-3.62 (m, 14H), 2.40 (t, J=2.4 Hz, 1H). To a solution of MMAE (10 mg, 0.0139 mmol) in 0.286 mL of N,N-Dimethylformamide (DMF) was added compound obtained above (12.8 mg, 0.0556 mmol) and 16 muL of acetic acid, followed by addition of 2 mg of sodium cyanoborohydride. The resulting mixture was stirred at ambient temperature for 2 h. The reaction mixture was concentrated and purified by flash column chromatography to give compound 25 (10 mg, 0.0107 mmole); HRMS (ESI-TOF, MNa+) calculated for C50H85N5O11Na 954.6138. found 954.6303.
 

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