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Chemical Structure| 1342906-74-4 Chemical Structure| 1342906-74-4

Structure of 1342906-74-4

Chemical Structure| 1342906-74-4

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Product Details of [ 1342906-74-4 ]

CAS No. :1342906-74-4
Formula : C12H9BrINO
M.W : 390.01
SMILES Code : IC1=NC=C(Br)C=C1OCC2=CC=CC=C2

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Application In Synthesis of [ 1342906-74-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1342906-74-4 ]

[ 1342906-74-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1342906-74-4 ]
  • [ 151169-74-3 ]
  • 3-benzyloxy-5-bromo-2-(2,3-dichlorophenyl)pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
56% With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In water; acetonitrile; at 120℃; for 2h;Inert atmosphere; To a solution of 3-benzyloxy-5-bromo-2-iodo-pyridine (1.2 g, 3.08 mmol) and (2,3-dichlorophenyl)boronic acid (588 mg, 3.08 mmol) in CH3CN (20 mL) and H20 (2 mL) was added K3P04 (2 g, 9.24 mmol) and Pd(dppf)C12CH2C12 (252 mg, 308.0 tmol) at 25C under N2. The mixture was stirred at 120 C for 2 hrs. The reaction mixture was diluted with H20 20 mL and extracted with EtOAc. The combined organic layers were washed with brine 100 mL, dried over Na2SO4, filtered and concentrated under reduced pressure. The remaining residue was purified by column chromatography to afford 3-benzyloxy-5- bromo-2-(2,3-dichlorophenyl)pyridine (700 mg, 1.71 mmol, 56 % yield) as a colorless oil. ‘H NMR (400 IVIFIz, Chloroform-cl) ppm 8.36 (s, 1 H) 7.5 1-7.47 (m, 2 H) 7.34-7.26 (m, 6 H) 5.09 (s, 2 H).
 

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