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Chemical Structure| 1345688-04-1 Chemical Structure| 1345688-04-1

Structure of 1345688-04-1

Chemical Structure| 1345688-04-1

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Product Details of [ 1345688-04-1 ]

CAS No. :1345688-04-1
Formula : C8H10N2O3
M.W : 182.18
SMILES Code : O=C(OCC)CN1N=CC=C1C=O

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Application In Synthesis of [ 1345688-04-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1345688-04-1 ]

[ 1345688-04-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1345688-04-1 ]
  • [ 124755-24-4 ]
  • [ 1345688-05-2 ]
YieldReaction ConditionsOperation in experiment
88% With sodium hydride; In tetrahydrofuran; at 0℃; for 0.666667h; (11b) Ethyl 6-hydroxypyrazolo[1,5-a]pyridine-7-carboxylate Into tetrahydrofuran (300 mL), <strong>[124755-24-4]ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate</strong> (22.9 g, 68.9 mmol) was dissolved, and the resulting mixture was ice cooled. To this, sodium hydride (content 55%) (3.01 g, 68.9 mmol) was added, to which a solution of ethyl (5-formyl-1H-pyrazol-1-yl)acetate (57.4 mmol) produced in Example 11 (11a) in tetrahydrofuran (85 mL) was further added, followed by stirring at 0C for 20 minutes.To this, sodium hydride (content 55%) (3.01 g, 68.9 mmol) was further added, followed by stirring at 0 C for 20 minutes. To the resulting reaction liquid, a saturated aqueous solution of ammonium chloride was added, followed by extraction with ethyl acetate. The combined organic layer was then dried over anhydrous sodium sulfate. After filtration, the solvent was distilled off under reduced pressure, and the residue thus obtained was purified by silica gel column chromatography (hexane : ethyl acetate = 3 : 1 - 2 : 1, V/V) to give the desired title compound (10.4 g, yield 88%).1H-NMR (CDCl3) ˜: 1.54 (3H, t, J = 7.2 Hz), 4.66 (2H, q, J = 7.2 Hz), 6.60 (1H, d, J = 2.4 Hz), 6.95 (1H, d, J = 9.5 Hz), 7.65 (1H, d, J = 9.5 Hz), 7.97 (1H, d, J = 2.4 Hz), 11. 60 (1H, s).
 

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