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[ CAS No. 1347759-13-0 ] {[proInfo.proName]}

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Chemical Structure| 1347759-13-0
Chemical Structure| 1347759-13-0
Structure of 1347759-13-0 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1347759-13-0 ]

CAS No. :1347759-13-0 MDL No. :MFCD28503354
Formula : C7H4Cl3NO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 224.47 Pubchem ID :-
Synonyms :

Safety of [ 1347759-13-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1347759-13-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1347759-13-0 ]
  • Downstream synthetic route of [ 1347759-13-0 ]

[ 1347759-13-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1347759-13-0 ]
  • [ 120422-90-4 ]
YieldReaction ConditionsOperation in experiment
54% With hydrazine In ethanol; water at 20℃; for 3.5 h; Intermediate 4A mixture ofIntermediate 3 (3.55 g, 15.8 mmol) and 35percent aqueous hydrazine (35 ml) in ethanol (35 ml) was stirred at rt for 3.5 hours. The reaction mixture was added to ice and extracted with ethyl acetate. The organic phase was washed with brine, dried and concentrated. The residue was purified by flash column chromatography on silica gel eluting with 3:1 petrol- ethyl acetate to give an off-white coloured solid (1.71 g, 54percent). 1H NMR (400 MHz, DMSO- cfB) δ ppm 2.64 (s, 3 H), 7.63 (s, 1 H).
0.74 g With hydrazine hydrate In ethanol at 20℃; for 40 h; To a solution of 1-(2,4,6-trichloro-pyridin-3-yl)-ethanone (1,75 gin ethanol, absolute (8,75 mL) was added hydrazinehydrate (0,76 mL). The reaction was stirred at room temperature over the weekend (40 h). The solvent was evaporated and water (10 mL) added. The aqueous phase was extracted with DCM (3 x 10 mL), the combined organic phases were dried (Na2504) and concentrated. The crude material was purified by Biotage Isolera FCC (5i02 50 g) eluting 10-30percent EtOAc in cyclohexane to give 0.74 g of product as an off white solid.Analysis: HPLC-MS: R1 = 1.15 mm (method P), M+H = 202/2041H NMR (DMSO, 500 MHz) 6 2.64 (3H, s), 7.64 (1 H, s)
Reference: [1] Patent: WO2011/141756, 2011, A1, . Location in patent: Page/Page column 50
[2] Patent: WO2017/42100, 2017, A1, . Location in patent: Page/Page column 50
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