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Chemical Structure| 1349151-83-2 Chemical Structure| 1349151-83-2

Structure of 1349151-83-2

Chemical Structure| 1349151-83-2

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Product Details of [ 1349151-83-2 ]

CAS No. :1349151-83-2
Formula : C13H14BrN3O2S
M.W : 356.24
SMILES Code : NC1=NC=C(C2=CC=C(S(=O)(C(C)C)=O)C=C2)N=C1Br
MDL No. :MFCD26393426

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Application In Synthesis of [ 1349151-83-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1349151-83-2 ]

[ 1349151-83-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1006-68-4 ]
  • [ 1349151-83-2 ]
  • [ 1432790-37-8 ]
YieldReaction ConditionsOperation in experiment
11 mg With palladium; triphenylphosphine; lithium tert-butoxide; In 1,4-dioxane; at 14 - 130℃; for 3h;Microwave irradiation; Example 2 Synthesis of 5-(4-(isopropylsulfonyl)phenyl)-3-(5-phenyloxazol-2-yl)pyrazin-2-amine Compound I-2 [0201] [0202] A mixture of 3-bromo-5-(4-isopropylsulfonylphenyl)pyrazin-2-amine (147 mg, 0.4126 mmol), <strong>[1006-68-4]5-phenyloxazole</strong> (49.91 mg, 0.3438 mmol), palladium; triphenylphosphane (39.73 mg, 0.03438 mmol) and 2-methylpropan-2-olate (Lithium Ion (1)) (55.05 mg, 0.6876 mmol) in dioxane (2 mL) was heated in a microwave at 130 C for 1 h and a further heated in a MW 2 h at 14 C. The reaction mixture was filtered through celite, the filtrate concentrated in vacuo, and the residue purified by reverse phase preparative HPLC [Waters Sunfire C18, mM, 100 column, gradient 10%-95% B (solvent A: 0.05% trifluoroacetic acid in water; solvent B: acetonitrile) over 16 minutes at 25 mL/minutes], combined fractions were freeze-dried to give 5-(4-(isopropylsulfonyl)phenyl)-3-(5-phenyloxazol-2-yl)pyrazin-2-amine Compound I-2 (11 mg, 6%). %). 1H NMR (400.0 MHz, DMSO-d6) δ 8.96 (s, 1H), 8.40 (d, J=8.5 Hz, 2H), 8.07 (s, 1H), 7.97 (d, J=8.5 Hz, 2H), 7.94-7.88 (m, 2H), 7.56 (dd, J=8.3, 7.0 Hz, 2H), 7.51-7.42 (m, 1H), 3.47 (p, J=6.8 Hz, 1H), 1.21 (d, J=6.8 Hz, 6H); LC/MS m/z 421.0 [M+H]+.
  • 2
  • [ 1349151-83-2 ]
  • [ 1232416-25-9 ]
 

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