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Chemical Structure| 1349184-43-5 Chemical Structure| 1349184-43-5

Structure of 1349184-43-5

Chemical Structure| 1349184-43-5

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Product Details of [ 1349184-43-5 ]

CAS No. :1349184-43-5
Formula : C14H20ClN3O2
M.W : 297.78
SMILES Code : O=C(N1CCC(C2=NC=CN=C2Cl)CC1)OC(C)(C)C
MDL No. :MFCD24467683

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Application In Synthesis of [ 1349184-43-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1349184-43-5 ]

[ 1349184-43-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1349184-43-5 ]
  • [ 56456-49-6 ]
  • tert-butyl 4-{3-[(4-chloro-2-fluorobenzyl)oxy]pyrazin-2-yl}piperidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
94% With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 90℃; for 18h;Inert atmosphere; Palladium(ll) acetate (271 mg, 1 .21 mmol), 1 ,T-binaphthalene-2,2'- diylbis(diphenylphosphane) (BINAP; 1 .51 g, 2.42 mmol), and cesium carbonate (13.1 mg, 40.3 mmol) were added to a solution of C7 (6.00 g, 20.1 mmol) and <strong>[56456-49-6](4-chloro-2-fluorophenyl)methanol</strong> (3.56 g, 22.2 mmol) in 1 ,4-dioxane (60 ml_). Nitrogen was bubbled through the suspension, after which the reaction mixture was stirred at 90 C for 18 hours and filtered. The filtrate was concentrated in vacuo and purified using chromatography on silica gel (Gradient: 3% to 20% EtOAc in petroleum ether) to afford C8 as a yellow gum. Yield: 7.96 g, 18.9 mmol, 94%.
 

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