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Chemical Structure| 1352306-36-5 Chemical Structure| 1352306-36-5

Structure of 1352306-36-5

Chemical Structure| 1352306-36-5

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Product Details of [ 1352306-36-5 ]

CAS No. :1352306-36-5
Formula : C9H8ClFO3
M.W : 218.61
SMILES Code : O=C(Cl)C1=C(OC)C=CC(OC)=C1F
MDL No. :MFCD19439919

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Application In Synthesis of [ 1352306-36-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1352306-36-5 ]

[ 1352306-36-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 35553-92-5 ]
  • [ 1352306-36-5 ]
  • [ 1352306-35-4 ]
YieldReaction ConditionsOperation in experiment
To a mixture of 2-fluoro-3,6-dimethoxybenzoic acid (4.8 g, 24 mmol) in anhydrous dichloromethane (75 mL) at 0 C, SOCI2 (14.2 g, 120 mmol) was slowly added followed by DMF (0.1 mL). The resulting mixture was stirred at room temperature for 2 h and concentrated in vacuo to give 2-fluoro-3,6-dimethoxybenzoyl chloride (5.2 g). To a solution of ethyl 2-(3- methoxyphenyl)acetate (4.7 g, 24 mmol) in anhydrous THF (40 mL) at -78 C, LiHMDS (1.0 M in THF, 36 mL) was added dropwise. The resulting solution was stirred at -78 C for 30 min and a solution of 2-fluoro-3,6-dimethoxybenzoyl chloride (5.2 g, 24 mmol) in anhydrous THF (60 ml) was added dropwise. The reaction mixture was stirred for additional 2 h at -78 C and quenched with saturated NH4CI. The mixture was extracted with ethyl acetate (3x200 mL). The combined organic layers were dried (Na2S04) and concentrated under reduced pressure to afford the title compound (7.8 g).
 

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