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Chemical Structure| 1352615-34-9 Chemical Structure| 1352615-34-9

Structure of 1352615-34-9

Chemical Structure| 1352615-34-9

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Product Details of [ 1352615-34-9 ]

CAS No. :1352615-34-9
Formula : C19H30BNO4
M.W : 347.26
SMILES Code : O=C(OC(C)(C)C)NC1=CC(C)=C(B2OC(C)(C)C(C)(C)O2)C=C1C

Safety of [ 1352615-34-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 1352615-34-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1352615-34-9 ]

[ 1352615-34-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1352615-34-9 ]
  • [ 117635-21-9 ]
  • [ 1362736-65-9 ]
YieldReaction ConditionsOperation in experiment
60% With Aliquat 336; sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In water; toluene; at 90℃; for 38h;Inert atmosphere; In the dry box the mixture of boronic acid pinacol ester,4, (6.44g, 18.55mmol), 1 ,4-dibromo-2,5-dihexylbenzene (3.75g, 9.27mmol), Aliquat 336 (0.8g), and Pd(PPh3) (0.536g, 0.464mmol) in degassed toluene (l OOmL) was prepared. Outside dry box, the degassed Na2CO3 (2.95g, 27.83mmol in 50 ml_ of water) solution was added to the former mixture under nitrogen, and then the resultant mixture was stirred at 90C for 38hrs. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over anhydrous MgSO4. Filtration, concentration of the filtrate, and then the silica column chromatography (0-4% ethyl acetate in hexane) provided the desired product (3.62g, 60% yield) as a white solid. This diboc-protected material was deprotected by the overnight reaction at room temperature with TFA solution (4ml_ of TFA in 30ml_ of DCM). The reaction mixture was concentrated under reduced pressure followed by the neutralization with saturated NaHCO3. Ethyl acetate extraction, drying over anhydrous MgSO4, concentration of the organic layer under reduced pressure, then silica column chromatography (30% ethyl acetate in hexane) provided the desired diamine material,8, (2.5g, 99% yield).
 

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