Alternatived Products of [ 1355729-43-9 ]
Product Details of [ 1355729-43-9 ]
CAS No. : | 1355729-43-9 |
MDL No. : | MFCD25476639 |
Formula : |
C8H7F2NO2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
187.14
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 1355729-43-9 ]
Application In Synthesis of [ 1355729-43-9 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1355729-43-9 ]
- 1
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[ 56026-36-9 ]
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[ 1355729-43-9 ]
- 2
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[ 10165-86-3 ]
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[ 1355729-43-9 ]
Yield | Reaction Conditions | Operation in experiment |
63.7% |
With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at 0 - 50℃; for 1.83333h; |
To a solution of the product of Example 828A (1.4 g, 8.48 mmol) in dichloromethane (75 mL) at 0 C was added bis(2-methoxyethyl)aminosulfur trifluoride (4.69 mL, 25.4 mmol) dropwise via a syringe pump over 30 minutes. The mixture was allowed to stir at 0 C for 20 minutes, then the ice bath was removed, and the mixture was allowed to warm to ambient temperature. The mixture was then allowed to stir for an additional 1 hour and was quenched with saturated, aqueous NaHC( (15 mL) and diluted with ethyl acetate (15 mL). The layers were separated, and the aqueous layer was extracted with ethyl acetate (3 x 7 mL). The combined organic fractions were dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified via column chromatography (Si(, 50% ethyl acetate/heptanes) to give the title compound (1.01 g, 5.40 mmol, 63.7% yield). MS (ESI+) m/z 188 (M+H)+. |