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Chemical Structure| 1356009-25-0 Chemical Structure| 1356009-25-0

Structure of 1356009-25-0

Chemical Structure| 1356009-25-0

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Product Details of [ 1356009-25-0 ]

CAS No. :1356009-25-0
Formula : C9H8N4O3
M.W : 220.18
SMILES Code : OC1=CC([N+]([O-])=O)=CC=C1N2N=C(C)N=C2

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Application In Synthesis of [ 1356009-25-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1356009-25-0 ]

[ 1356009-25-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 383-62-0 ]
  • [ 1356009-25-0 ]
  • 1-(2-(difluoromethoxy)-4-nitrophenyl)-3-methyl-1H-1,2,4-triazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
70.1% With potassium carbonate; In N,N-dimethyl-formamide; at 70℃; for 5h; 1 -(2-(Difluoromethoxy)-4-nitrophenyl)-3 -methyl-i H-i, 2, 4-triazole To a solution of 2-(3 -methyl-i H-i ,2,4-triazol- 1 -yl)-5 -nitrophenol (5 g, 22.71 mmol), potassium carbonate (3.14 g, 22.71 mmol) in DMF (30 mL) was added <strong>[383-62-0]ethyl chlorodifluoroacetate</strong> (3.60 g, 22.71 mmol) and heated at 70 C for 5 h. The DMF wasevaporated under high vacuum to get a dark brown solid, which was suspended in ethyl acetate (300 mL) and washed with water (2 X 50 mL) and brine (50 mL). The solution was dried over sodium sulphate, filtered, and evaporated under reduced pressure to provide a brown solid that was further purified by chromatography ( ISCO) using 40- 60% ethyl acetate as a mobile phase to give 1 -(2-(difluoromethoxy)-4-nitrophenyl)-3-methyl-iH-i,2,4-triazole (10 g, 3i.8mmol, 70.1% yield) as a light brown solid. LC/MS (M+H) = 271.2 ?H NMR (400 MHz, CHLOROFORM-d) oe ppm 8.74 (s, 1 H) 8.23-8.27 (m, 2 H), 8.15 (d, J=8.8 Hz, 1 H), 6.70 (t, J73 Hz, 1 H).
 

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