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[ CAS No. 1357289-08-7 ] {[proInfo.proName]}

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Chemical Structure| 1357289-08-7
Chemical Structure| 1357289-08-7
Structure of 1357289-08-7 * Storage: {[proInfo.prStorage]}
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CAS No. :1357289-08-7 MDL No. :MFCD28978324
Formula : C20H23NO8 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 405.40 Pubchem ID :-
Synonyms :

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

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[ 1357289-08-7 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1357289-08-7 ]
  • [ 72235-52-0 ]
  • [ 1229006-21-6 ]
YieldReaction ConditionsOperation in experiment
97% With acetic acid In toluene at 90℃; for 7 h; 2,4-difluorobenzylamine (209 mg, 1.4 mmol) and acetic acid (88 mg, 1.4 mmol) were added to a toluene (5.4 mL) suspension of compound 12B (539 mg, 1.3 mmol) at room temperature, and the mixture was then heated to 90°C and stirred for 7 hours. After the completion of reaction, the solvent was distilled off under reduced pressure, and the obtained residue was purified by silica gel chromatography (n-hexane:ethyl acetate = 3 : 7 (v/v)) to obtain 666 mg (yield: 97percent) of compound 13C as a pale yellow oil. 1H-NMR (CDCl3) δ: 3.37 (6H, s), 3.79 (3H, s), 4.01 (2H, d, J = 5.0 Hz), 4.47 (1H, t, J = 5.0 Hz), 4.65 (2H, d, J = 6.0 Hz), 5.26 (2H, s), 6.78-6.86 (2H, m), 7.30-7.42 (6H, m), 8.42 (1H, s), 10.41 (1H, t, J = 6.0 Hz).
Reference: [1] Patent: EP2602260, 2013, A1, . Location in patent: Paragraph 0184
[2] Organic Process Research and Development, 2016, vol. 20, # 8, p. 1461 - 1468
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