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[ CAS No. 1360451-37-1 ] {[proInfo.proName]}

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Chemical Structure| 1360451-37-1
Chemical Structure| 1360451-37-1
Structure of 1360451-37-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1360451-37-1 ]

CAS No. :1360451-37-1 MDL No. :MFCD23703262
Formula : C12H9BrF3N Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 304.11 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 1360451-37-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1360451-37-1 ]

[ 1360451-37-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 474024-36-7 ]
  • [ 109-64-8 ]
  • [ 1360451-37-1 ]
YieldReaction ConditionsOperation in experiment
84% With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 12h; 1 1) (4-Trifluoromethylphenyl)cyclobutanecarbonitrile Sodium hydride (380 mg; 9.5 mmol; content 60%) is suspended in 4 ml of DMSO. 1,3-Dibromopropane (920 mg; 4.5 mmol) and (2-bromo-4-trifluoromethylphenyl)carbonitrile are dissolved in 10 ml of DMSO and added dropwise to the sodium hydride suspension. The batch is stirred at RT for 12 h. 10 ml of water are then added, and the mixture is extracted to exhaustion with ethyl acetate. Conventional further work-up and purification on silica gel (petroleum ether/ethyl acetate=95:5) gives (4-trifluoromethylphenyl)cyclobutanecarbonitrile (965 mg, 84%); 1H NMR (DMSO-d6) δ [ppm] J [Hz]: 8.09 (d, 1H), 7.85 (dd, 1H), 7.68 (d, 1H), 2.81-3.03 (m, 2H), 2.65-2.81 (m, 2H), 2.18-2.44 (m, 1H), 1.82-2.00 (m, 1H).
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