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Chemical Structure| 136138-26-6 Chemical Structure| 136138-26-6

Structure of 136138-26-6

Chemical Structure| 136138-26-6

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Product Details of [ 136138-26-6 ]

CAS No. :136138-26-6
Formula : C14H12INO2
M.W : 353.16
SMILES Code : O=C(NC1=CC=CC=C1I)C2=CC=CC=C2OC

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Application In Synthesis of [ 136138-26-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 136138-26-6 ]

[ 136138-26-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 128156-54-7 ]
  • [ 136138-26-6 ]
  • methyl 2-[2-[(2-methoxybenzoyl)amino]phenyl]-1,3-benzoxazole-4-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
82% With copper(l) iodide; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In toluene; for 20.0h;Inert atmosphere; Reflux; General procedure: To a degassed solution (N2 was purged for 10 min) of <strong>[128156-54-7]methyl 1,3-benzoxazole-4-carboxylate</strong> (150 mg, 0.847mmol) and N-(2-iodophenyl)benzamide 2a (273 mg, 0.847 mmol) in anhydrous toluene (4ml) , CuI (32 mg, 0.169 mmol), xantphos (98 mg, 0.169 mmol), Pd(OAc)2 (10 mg, 0.042 mmol), Cs2CO3 (685 mg, 2.117 mmol) were added at room temperature under nitrogen atmosphere. Reaction mixture was continued for 20 hours at reflux condition. After the completetion of the reaction (monitored by TLC), Reaction mixture was filtered through celite bed and washed with methanol (10 ml),filtrate was concentrated. Crude mass which was purified by column chromatography over silica gel (230-400 mesh) using DCM-Methanol (1:9) as elutant to affordthe products 3a (284 mg) as white solid. All the other compounds 3b-3r were prepared similarly following the above procedure.
 

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