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Chemical Structure| 1361941-18-5 Chemical Structure| 1361941-18-5

Structure of 1361941-18-5

Chemical Structure| 1361941-18-5

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Product Details of [ 1361941-18-5 ]

CAS No. :1361941-18-5
Formula : C9H9NOS
M.W : 179.24
SMILES Code : O=C1NCC2=C1SC(C3CC3)=C2
MDL No. :MFCD24620083

Safety of [ 1361941-18-5 ]

Application In Synthesis of [ 1361941-18-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1361941-18-5 ]

[ 1361941-18-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1361941-18-5 ]
  • [ 156001-49-9 ]
  • 5-(4-bromo-2-methylbenzyl)-2-cyclopropyl-4H-thieno[2,3-c]pyrrol-6(5H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
12% [01 69j To a mixture of 2-cyclopropyl-4H-thieno [2,3 -c]pyrrol-6(5H)-one (150 mg, 0.8 mmol) in dry DMF (6 ml) was added 60% NaH (50 mg, 1.3 mmol) at 0 C. The mixture was stirred at rt for 10 mm after which 4-bromo- 1 -(bromomethyl)-2-methylbenzene (264 mg, 1.0 mmol) was added. The mixture was stirred at rt for 1 h. Then the reaction was quenched by water (5 mL) and diluted EtOAc (100 mL), washed by brine (40 mL). The organic phase was dried and concentrated to give a crude residue which was purified by silica gel column chromatography (petroleum ether/EtOAc, 8:1 to 5:1) to give the compound 5 -(4-bromo-2-methylbenzyl)-2- cyclopropyl-4H-thieno[2,3-c]pyrrol-6(5H)-one (35 mg, yield: 12%) as a light yellow solid. ESIMS (M+H): 362.1.
  • 2
  • [ 1361941-18-5 ]
  • [ 156001-49-9 ]
  • 2-cyclopropyl-5-(2-methyl-4-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)benzyl)-4H-thieno[2,3-c]pyrrol-6(5H)-one [ No CAS ]
 

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