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Chemical Structure| 1366131-26-1 Chemical Structure| 1366131-26-1

Structure of 1366131-26-1

Chemical Structure| 1366131-26-1

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Product Details of [ 1366131-26-1 ]

CAS No. :1366131-26-1
Formula : C9H6BrClN2
M.W : 257.51
SMILES Code : NC1=NC2=CC=C(Cl)C=C2C=C1Br
MDL No. :MFCD31635635

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Application In Synthesis of [ 1366131-26-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1366131-26-1 ]

[ 1366131-26-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1366131-26-1 ]
  • [ 874219-34-8 ]
  • [ 1366132-01-5 ]
YieldReaction ConditionsOperation in experiment
34% With potassium acetate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In 1,2-dimethoxyethane; water; at 80.0℃;Inert atmosphere; A mixture of 3-bromo-6-chloro-2-quinolinamine (3 g, 1 1.65 mmol), [3- (aminocarbonyl)-4-fluorophenyl]boronic acid (2.77 g, 15.14 mmol), potassium acetate (3.43 g, 34.9 mmol ) and PdCI2(dppf)-CH2CI2 adduct (0.953 g, 1.165 mmol) in 1 ,2-Dimethoxyethane (DME) ( 50 mL) and water (12.5 mL) was heated under nitrogen atmosphere at 80 C overnight. Cooled down and loaded the reaction solution to a column and purified by columnchromatography (silica gel, EtOAc/Hexane from 0-50%) to give the desire product. (1.52 g, 34 %). LCMS (ES+) m/z 316.
 

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