Home Cart 0 Sign in  

[ CAS No. 13676-00-1 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 13676-00-1
Chemical Structure| 13676-00-1
Structure of 13676-00-1 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 13676-00-1 ]

Related Doc. of [ 13676-00-1 ]

Alternatived Products of [ 13676-00-1 ]

Product Details of [ 13676-00-1 ]

CAS No. :13676-00-1 MDL No. :MFCD08688617
Formula : C10H9NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 175.18 Pubchem ID :-
Synonyms :

Safety of [ 13676-00-1 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501 UN#:
Hazard Statements:H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 13676-00-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 13676-00-1 ]
  • Downstream synthetic route of [ 13676-00-1 ]

[ 13676-00-1 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 13676-00-1 ]
  • [ 577967-89-6 ]
Reference: [1] Patent: WO2012/48181, 2012, A1,
[2] Patent: WO2012/83165, 2012, A1,
  • 2
  • [ 13676-00-1 ]
  • [ 13676-02-3 ]
Reference: [1] Journal of Medicinal Chemistry, 2004, vol. 47, # 22, p. 5405 - 5417
[2] Patent: WO2004/24731, 2004, A1, . Location in patent: Page 56
[3] Patent: US2007/173508, 2007, A1, . Location in patent: Page/Page column 84
[4] Patent: US2002/82276, 2002, A1,
  • 3
  • [ 13676-00-1 ]
  • [ 13676-02-3 ]
YieldReaction ConditionsOperation in experiment
86% for 2 h; Reflux A solution of 6- methoxyquinolin-2-ol (400 mg, 2.29 mmol) in POCI3 (5.0 mL) was refluxed for 2 hours. The solvent was removed under reduced pressure and the residue was dissolved in EtOAc (50 mL), the organic layer was washed with saturated NaHC03 (30 mL x2), dried over Na2S04, filtered and concentrated to give the crude product, which was purified by silica gel column (PE / EtOAc=10 / 1) to give 2-chloro-6-methoxyquinoline (380 mg, yield 86percent) as a solid. 1H NMR (CDC13 400 MHz): δ 7.92 (d, J = 8.4 Hz, 1H), 7.85 (d, J = 9.2 Hz, 1H), 7.32-7.25 (m, 2H), 7.00 (d, J = 2.4 Hz, 1H), 3.86 (s, 3H).
86% for 2 h; Reflux A solution of 6- methoxyquinolin-2-ol (400 mg, 2.29 mmol) in POCI3 (5.0 mL) was refluxed for 2 hours. The solvent was removed under reduced pressure and the residue was dissolved in EtOAc (50 mL), the organic layer was washed with saturated NaHCC>3 (30 mL x2), dried over Na2S04, filtered and concentrated to give the crude product, which was purified by silica gel column (PE / EtOAc=10 / 1) to give 2-chloro-6-methoxyquinoline (380 mg, yield 86percent) as a solid. *H NMR (CDC13 400 MHz): δ 7.92 (d, J = 8.4 Hz, 1H), 7.85 (d, J = 9.2 Hz, 1H), 7.32-7.25 (m, 2H), 7.00 (d, / = 2.4 Hz, 1H), 3.86 (s, 3H).
Reference: [1] Patent: WO2012/48181, 2012, A1, . Location in patent: Page/Page column 74
[2] Patent: WO2012/83165, 2012, A1, . Location in patent: Page/Page column 91
[3] Ann. Inst. Pasteur, 1930, vol. 44, p. 719,736
  • 4
  • [ 13676-00-1 ]
  • [ 19315-93-6 ]
Reference: [1] Heterocyclic Communications, 2008, vol. 14, # 3, p. 183 - 186
[2] Journal of Medicinal Chemistry, 1986, vol. 29, # 10, p. 2024 - 2028
Same Skeleton Products
Historical Records