There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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CAS No. : | 137178-88-2 | MDL No. : | MFCD07368290 |
Formula : | C6H3BrClNO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | IJJINPZOASSMGD-UHFFFAOYSA-N |
M.W : | 220.45 | Pubchem ID : | 19090771 |
Synonyms : |
|
Signal Word: | Danger | Class: | 8 |
Precautionary Statements: | P280-P305+P351+P338-P310 | UN#: | 3261 |
Hazard Statements: | H314 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2 h; | Oxalyl chloride (0.24 mmol) and 5 drops of N, N-dimethylformamide was added dropwise at room temperature, mixed with 5-bromo-pyrazolPiperidine carboxylic acid (0.05 mmol) in methylene chloride (80 ml). Was stirred at room temperature for 2 hours, the solvent was removed by distillation under reduced pressure to giveChloride 5.4 g (100percent). |
99% | at 80℃; for 2 h; | Thionyl chloride (10 ml, 137 mmol) was added to 5-bromopicolinic acid (5.00 g, 24.75 mmol). A drop of DMF was added, and the mixture was heated at 80 °C for 2 h. The excess thionyl chloride was removed to afford 5-bromopicolinoyl chloride (5.413 g, 24.55 mmol, 99 percent yield) as a pale yellow solid. An aliquot was quenched with methanol to afford methyl 5-bromopicolinate. MS (ESI, pos. ion) m/z: 216, 218 (M + 1). |
93% | for 2 h; Inert atmosphere; Reflux | Thionyl chloride (10 mL, 150 mmol) was added to solid 5-bromopicolinic acid (1 .2 g, 6 mmol) at ambient temperature under N2. The resulting mixture was refluxed for 2 h and the volatiles were removed in vacuo. The crude acid chloride was dissolved in dry DCM (20 mL) and the solution was slowly added at 0 °C to a solution of 2-amino-2-methylpropan-1-01 (1.6 g, 18 mmol) in DCM (5 mL). After stirring 48 h at ambient temperature, solvents were removed in vacuo and the crude product was purified by flash chromatography on silica gel (PEIEA= 100/1 to 5/1) to the title compound (1.5 g, 93 percent) as a white solid. LCMS: [M+H] = 273.1. |
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