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Chemical Structure| 1374451-83-8 Chemical Structure| 1374451-83-8

Structure of 1374451-83-8

Chemical Structure| 1374451-83-8

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Product Details of [ 1374451-83-8 ]

CAS No. :1374451-83-8
Formula : C17H27BN2O4
M.W : 334.22
SMILES Code : O=C(OC(C)(C)C)NCC1=NC=C(B2OC(C)(C)C(C)(C)O2)C=C1
MDL No. :N/A

Safety of [ 1374451-83-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 1374451-83-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1374451-83-8 ]

[ 1374451-83-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 19932-85-5 ]
  • [ 1374451-83-8 ]
  • 6-(6-(aminomethyl)pyridin-3-yl)benzooxazol-2(3H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In water; N,N-dimethyl-formamide; at 140℃; for 0.5h;Microwave irradiation; To a deoxygenated mixture of tert-butyl ( (5- (4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborolan-2- yl) pyridin-2-yl) methyl) carbamate (62.5 mg, 0.187 mmol) , 6-bromobenzo oxazol-2 (3H) -one (40.0 mg, 0.187 mmol) , cesium carbonate (183 mg, 0.561 mmol) in DMF (0.93 mL) was added PdCl2(dppf) (21 mg, 0.028 mmol) and water (0.033 mL, 1.9 mmol) and the resulting mixture was heated at 140 for 30 min under microwave irradiation. The mixture was cooled and partitioned between EtOAc and water. The organic layer was washed with brine, dried over magnesium sulfate, and concentrated. The residue was purified by column chromatography on silica gel (0-5 MeOH in EtOAc) to afford the Boc protected intermediate. To a solution of this intermediate (18 mg, 0.053 mmol) in DCM (0.18 mL) was bubbled gaseous HCl for 1 min. The mixture was stirred for 1 h and then concentrated to afford the title compound. MS: m/z 242.24 (M + 1)
 

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