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Chemical Structure| 1374973-19-9 Chemical Structure| 1374973-19-9

Structure of 1374973-19-9

Chemical Structure| 1374973-19-9

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Product Details of [ 1374973-19-9 ]

CAS No. :1374973-19-9
Formula : C11H20F2N2O2
M.W : 250.29
SMILES Code : O=C(OC(C)(C)C)N[C@@H]1[C@H](N)C(F)(F)CCC1
MDL No. :MFCD32704836

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Application In Synthesis of [ 1374973-19-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1374973-19-9 ]

[ 1374973-19-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1374973-19-9 ]
  • [ 3177-24-0 ]
  • [ 1439908-36-7 ]
  • 2
  • [ 1374973-19-9 ]
  • [ 3177-24-0 ]
  • [ 1439908-36-7 ]
  • [ 1439908-38-9 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 100℃; for 0.333333h; 2,4-Dichloropyrimidine-5-carbonitrile (571 mg, 3.28 mmol) was dissolved in 25 mL NMP. To it were added tert-butyl (1S,2S)-2-amino-3,3-difluorocyclohexylcarbamate (820 mg, 3.28 mmol) and DIEA (1.14 mL, 6.56 mmol). The mixture was stirred at 100°C for 20 m to afford major product tert-butyl (lS,2S)-2-(4-chloro-5-cyanopyrimidin-2-ylamino)-3,3- difiuorocyclohexylcarbamate (A17, UV=268nm) and minor product tert-butyl (lS,2S)-2-(2- chloro-5-cyanopyrimidin-4-ylamino)-3,3-difluorocyclohexylcarbamate (A18, UV=249, 301nm) in the ratio of 2.6:1. The mixture was cooled to RT, diluted with EtOAc, washed with brine three times, concentrated in vacuo and subjected to flash column to separate A17 and A 18.
 

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