[ CAS No. 1375110-97-6 ] {[proInfo.proName]}

Name: 1375110-97-6|2-Methylimidazo[1,2-a]pyridin-7-amine|97%
Brand: Ambeed
SKU: A383498
Rating: 97 (27 reviews)

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Quality Control of [ 1375110-97-6 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 1375110-97-6 ]

CAS No. :	1375110-97-6	MDL No. :	MFCD24645609
Formula :	C₈H₉N₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	VWVRRNUIGQUURB-UHFFFAOYSA-N
M.W :	147.18	Pubchem ID :	60145038
Synonyms :

Calculated chemistry of [ 1375110-97-6 ]

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	9
Fraction Csp3 :	0.12
Num. rotatable bonds :	0
Num. H-bond acceptors :	1.0
Num. H-bond donors :	1.0
Molar Refractivity :	44.56
TPSA :	43.32 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.15 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.55
Log Po/w (XLOGP3) :	1.48
Log Po/w (WLOGP) :	1.23
Log Po/w (MLOGP) :	0.44
Log Po/w (SILICOS-IT) :	0.68
Consensus Log Po/w :	1.07

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.29
Solubility :	0.754 mg/ml ; 0.00512 mol/l
Class :	Soluble
Log S (Ali) :	-2.0
Solubility :	1.48 mg/ml ; 0.0101 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-2.09
Solubility :	1.19 mg/ml ; 0.00807 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.61

Safety of [ 1375110-97-6 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 1375110-97-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1375110-97-6 ]

[ 1375110-97-6 ] Synthesis Path-Downstream 1~14

1
[ 1042981-08-7 ]
[ 1375110-97-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: hydrazine hydrate / ethanol / 100 h / Reflux 2: hydrogenchloride; sodium nitrite / water / 5 - 20 °C 3: Reflux 4: water; sodium hydroxide / 17 h / Reflux

Reference： [1]Masurier, Nicolas; Debiton, Eric; Jacquemet, Alicia; Bussière, Antoine; Chezal, Jean-Michel; Ollivier, Anthony; Tétégan, Daté; Andaloussi, Mounir; Galmier, Marie-Joseph; Lacroix, Jacques; Canitrot, Damien; Teulade, Jean-Claude; Gaudreault, René C.; Chavignon, Olivier; Moreau, Emmanuel [European Journal of Medicinal Chemistry, 2012, vol. 52, p. 137 - 150]

2
[ 13362-30-6 ]
[ 1375110-97-6 ]

Reference： [1]European Journal of Medicinal Chemistry,2012,vol. 52,p. 137 - 150

3
[ 1375110-90-9 ]
[ 1375110-97-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: hydrogenchloride; sodium nitrite / water / 5 - 20 °C 2: Reflux 3: water; sodium hydroxide / 17 h / Reflux

4
[ 1375110-93-2 ]
[ 1375110-97-6 ]

Yield	Reaction Conditions	Operation in experiment
80%	With water; sodium hydroxide for 17h; Reflux;	4.1.9. General method for the synthesis of 2-substituted 7-aminooimidazo[1,2-a]pyridine derivatives 26(g-j) General procedure: A stirred solution of the appropriate carbamate 25(g-j) (2.0 g, 9.76 mmol) in 5 N aqueous NaOH (100 mL) was refluxed for 7 h. After cooled to room temperature, the solution was diluted with H2O (100 mL), extracted with CH2Cl2 (3 × 50 mL), dried over Na2SO4, filtered and evaporated in vacuo. The crude product was purified on neutral alumina eluted with (CH2Cl2/EtOH, 99/1, v/v) to afford the appropriate amine 26(g-j).

Reference： [1]Location in patent: experimental part Masurier, Nicolas; Debiton, Eric; Jacquemet, Alicia; Bussière, Antoine; Chezal, Jean-Michel; Ollivier, Anthony; Tétégan, Daté; Andaloussi, Mounir; Galmier, Marie-Joseph; Lacroix, Jacques; Canitrot, Damien; Teulade, Jean-Claude; Gaudreault, René C.; Chavignon, Olivier; Moreau, Emmanuel [European Journal of Medicinal Chemistry, 2012, vol. 52, p. 137 - 150]

5
[ 1375110-97-6 ]
ethyl 2-methyl-10-oxo-7,10-dihydroimidazo[2,1-f]-1,6-naphthyridine-8-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: toluene / 21 h / Reflux 2: trichlorophosphate / 6 h / 100 °C

6
[ 1375110-97-6 ]
[ 87-13-8 ]
[ 1375111-01-5 ]

Yield	Reaction Conditions	Operation in experiment
90%	In toluene for 21h; Reflux;	4.1.10. General method for the synthesis of ethyl N-(imidazo[1,2-a]pyridin-7-yl)aminomethylenemalonate 27(f-j) and N-(imidazo[1,2-a]pyridin-8-yl)aminomethylenemalonate 31(g-j) derivatives General procedure: Diethyl ethoxymethylenemalonate (7.0 g, 32.0 mmol) was added to a stirred solution of the corresponding amine 5, 26(f-i), 30(f-i) (20.0 mmol) in dry toluene. The mixture was refluxed for 10 h and then cooled to room temperature. After removal of the solvent, the residue was purified by chromatography (alumina/CH2Cl2) to provide compound 27(f-j) or 31(g-j).

7
C₉H₇N₅O [ No CAS ]
[ 1375110-97-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: Reflux 2: water; sodium hydroxide / 17 h / Reflux

8
[ 1375110-97-6 ]
6-(4-((2,5-dichloropyrimidin-4-yl)amino)piperidin-1-yl)pyridazine-3-carbonitrile [ No CAS ]
6-(4-((5-chloro-2-((2-methylimidazo[1,2-a]pyridin-7-yl)amino)pyrimidin-4-yl)amino)piperidin-1-yl)pyridazine-3-carbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
48%	With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,4-dioxane at 100℃; for 3h;	27 Example 27 6-(4-((5-chloro-2-((2-methylimidazo[1,2-a]pyridin-7-yl)amino)pyrimidin-4-yl)amino)piperidin-1-yl)pyridazine-3-carbonitrile To a suspension of 6-(4-((2,5-dichloropyrimidin-4-yl)amino)piperidin-l- yl)pyridazine-3 -carbonitrile (0.15 g, 0.43 mmol) in anhydrous l,4-dioxane (10 mL) were added 2-methylimidazo[l,2-a]pyridin-7-amine (0.097 g, 0.66 mmol), Pd(OAc)2 (0.020 g, 0.087 mmol), BINAP (0.055 g, 0.089 mmol) and Cs2C03 (0.30 g, 0.92 mmol). The mixture was degassed and refilled with N2 for several times and then heated to 100 °C and stirred for 3 h. The mixture was concentrated in vacuo. The residue was purified by silica gel column chromatography (DCM/(a solution of NH3 in MeOH (3M)) (v/v) = 100/1 to 50/1 to 30/1), to give the crude product. The crude product was stirred with EtOAc (3 mL), filtered and the filter cake was collected and dried in vacuo to afford the title compound as a white solid (95 mg, yield 48%).MS (ESI, pos. ion) m/z: 461.2 [M+H]+;HRMS (ESI, pos. ion) m/z: 461.1716 [M+H]+, calculated value for C22H22CIN10 [M+H]+ is 461.1712;1H NMR (400 MHz, DMSO-^) d (ppm): 9.51 (s, 1H), 8.26 (d, J = 7.3 Hz, 1H), 8.08-8.01 (m, 2H), 7.88 (d, J= 9.7 Hz, 1H), 7.49-7.40 (m, 2H), 7.06 (dd, J= 7.4, 1.9 Hz, 1H), 7.02 (d, J= 7.8 Hz, 1H), 4.70-4.58 (m, 2H), 4.45-4.32 (m, 1H), 3.29-3.20 (m, 2H), 2.24 (s, 3H), 2.12-2.01 (m, 2H), 1.77-1.62 (m, 2H);13C NMR (100 MHz, DMSO-^): d 159.11, 158.21, 157.26, 153.81, 145.85, 142.40, 137.78, 131.58, 128.82, 126.16, 117.94, 111.63, 108.73, 107.14, 104.63, 100.49, 48.68, 44.33, 30.91, 14.81.
48%	With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,4-dioxane at 100℃; for 3h; Inert atmosphere;	27 Example 27 6-(4-((5-Chloro-2-((2-methylimidazo[1,2-a]pyridin-7-yl)amino)pyrimidin-4-yl)amino)piperidine- 1-yl)pyridazine-3-carbonitrile To 6-(4-((2,5-dichloropyrimidin-4-yl)amino)piperidin-1-yl)pyridazine-3-carbonitrile (0.15 g, 0.43 mmol)Anhydrous 1,4-dioxane (10 mL)Into the suspension2-methylimidazo[1,2-a]pyridin-7-amine (0.097 g, 0.66 mmol),Pd(OAc) 2 (0.020 g, 0.087 mmol),BINAP (0.055g, 0.089mmol)And Cs2CO3 (0.30 g, 0.92 mmol).The reaction mixture is exhausted of air,And filled with nitrogen several times,Raise the temperature to 100 ° C and stir the reaction for 3 hours.It was then concentrated under reduced pressure.The residue was purified by silica gel column chromatography (EtOAc EtOAc EtOAcThe crude product was obtained.The resulting crude was stirred in EtOAc (3 mLThe collected filter cake is dried under reduced pressure.The title compound was obtained as a white solid (95 mg, yield 48%).

Reference： [1]Current Patent Assignee: SHENZHEN DONGYANGGUANG INDUSTRIAL DEVELOPMENT CO LTD - WO2019/99311, 2019, A1 Location in patent: Paragraph 000451
[2]Current Patent Assignee: SHENZHEN DONGYANGGUANG INDUSTRIAL DEVELOPMENT CO LTD; CALITOR SCIENCES LLC - CN109776522, 2019, A Location in patent: Paragraph 0949; 0950; 0951; 0952; 0953; 0954; 0955

9
[ 84249-14-9 ]
[ 1375110-97-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / water / 12 h / Reflux 2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 80 °C 3: hydrogenchloride / ethyl acetate / 7 h / 20 °C
	Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / water / 12 h / Reflux 2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 80 °C 3: hydrogenchloride / ethyl acetate / 7 h / 20 °C

Reference： [1]Current Patent Assignee: SHENZHEN DONGYANGGUANG INDUSTRIAL DEVELOPMENT CO LTD - WO2019/99311, 2019, A1
[2]Current Patent Assignee: SHENZHEN DONGYANGGUANG INDUSTRIAL DEVELOPMENT CO LTD; CALITOR SCIENCES LLC - CN109776522, 2019, A

10
[ 1375110-97-6 ]
4-((2,5-dichloro-pyrimidin-4-yl)(methyl)amino)-3-ethylpiperidine-1-carboxylic acid tert-butylester [ No CAS ]
4-((5-chloro-2-((2-methylimidazo[1,2-a]pyridin-7-yl)amino)pyrimidin-4-yl)(methyl)amino)-3-ethylpiperidin-1-carboxylate tert-butyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
58%	With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,4-dioxane Reflux;	8.5 Step 5) tert-butyl 4-((5-chloro-2-((2-methylimidazo[1,2-a]pyridin-7-yl)amino)pyrimidin-4-yl)(methyl)amino)-3-ethylpiperidine-1-carboxylate A mixture of /er/-butyl 4-((2,5-dichloropyrimidin-4-yl)(methyl)amino)-3- ethylpiperidine-l-carboxylate (208 mg, 0.5343 mmol), 2-methylimidazo[l,2-a]pyridin-7-amine (70 mg, 0.47561 mmol), Pd(OAc)2 (11.5 mg, 0.0512 mmol), BINAP (28.6 mg, 0.0459 mmol) and Cs2C03 (316.7 mg, 0.9720 mmol) was dissolved in l,4-dioxane (15 mL). The reaction mixture was heated to reflux and stirred overnight and then concentrated in vacuo. The residue was purified by silica gel column chromatography (DCM/MeOH(v/v) = 40/1) to give the title compound as a yellow solid (140 mg, yield 58%).MS (ESI, pos. ion) m/z: 500.3 [M+H]+.
58%	With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,4-dioxane Reflux;	8.5 Step 5) 4-((5-Chloro-2-((2-methylimidazo[1,2-a]pyridin-7-yl)amino)pyrimidin-4-yl)(methyl)amino)-3 -ethyl piperidine-1-carboxylic acid tert-butyl ester will4-((2,5-dichloropyrimidin-4-yl)(methyl)amino)-3-ethylpiperidine1-carboxylate(208 mg, 0.5343 mmol),2-methylimidazo[1,2-a]pyridine-7-amine (70 mg, 0.47561 mmol),Pd(OAc) 2 (11.5 mg, 0.0512 mmol),BINAP (28.6 mg, 0.0459 mmol) and Cs2CO3 (316.7 mg, 0.9720 mmol)The mixture was dissolved in 1,4-dioxane (15 mL).The resulting mixture was warmed to reflux and stirred overnight.After the reaction was completed, it was concentrated under reduced pressure.The residue obtained was purified by silica gel column chromatography (EtOAc / EtOAcThe title compound was obtained as a yellow solid (140 mg, yield 58%).

Reference： [1]Current Patent Assignee: SHENZHEN DONGYANGGUANG INDUSTRIAL DEVELOPMENT CO LTD - WO2019/99311, 2019, A1 Location in patent: Paragraph 000383
[2]Current Patent Assignee: SHENZHEN DONGYANGGUANG INDUSTRIAL DEVELOPMENT CO LTD; CALITOR SCIENCES LLC - CN109776522, 2019, A Location in patent: Paragraph 0652; 0669; 0670; 0671

11
[ 1194375-40-0 ]
[ 1375110-97-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 80 °C 2: hydrogenchloride / ethyl acetate / 7 h / 20 °C

Reference： [1]Current Patent Assignee: SHENZHEN DONGYANGGUANG INDUSTRIAL DEVELOPMENT CO LTD - WO2019/99311, 2019, A1 Current Patent Assignee: SHENZHEN DONGYANGGUANG INDUSTRIAL DEVELOPMENT CO LTD; CALITOR SCIENCES LLC - CN109776522, 2019, A

12
N-(diphenylmethylene)-2-methylimidazo[1,2-a]pyridin-7-amine [ No CAS ]
[ 1375110-97-6 ]

Yield	Reaction Conditions	Operation in experiment
33%	With hydrogenchloride In ethyl acetate at 20℃; for 7h;	8.4 Step 4) 2-methylimidazo[1,2-a]pyridin-7-amine A mixture of N-(diphenylmethylene)-2-methylimidazo[l,2-a]pyridin-7-amine (580 mg, 1.863 mmol) in a solution of hydrogen chloride in EtOAc (20 mL, 30 mmol, 1.5 M) was stirred at rt for 7 hours and then washed with water (50 mL x 2). The combined aqueous layers were adjusted to pH = 10 with saturated Na2C03 aqueous solution, and the resulting mixture was extracted with a mixed solvent of DCM/MeOH (10/1 (v/v), 150 mL x 4). The combined organic layers were dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (DCM/(a solution of NH3 in MeOH (7M)) (v/v) = 40/1 ) to give the title compound as a light yellow solid (90 mg, yield 33%).MS (ESI, pos. ion) m/z: 148.20 [M+H]+; 1H NMR (400 MHz, CDCl3) d (ppm): 7.73 (d, J= 7.2 Hz, 1H), 7.05 (s, 1H), 6.56 (d, J= 1.6 Hz, 1H), 6.19 (dd, j= 7.2, 2.2 Hz, 1H), 3.91 (s, 2H), 2.34 (s, 3H).
33%	With hydrogenchloride In ethyl acetate at 20℃; for 7h;	8.4 Step 4) 2-Methylimidazo[1,2-a]pyridin-7-amine N-(Diphenylmethylene)-2-methylimidazo[1,2-a]pyridine-7-amine (580 mg, 1.863 mmol)Hydrogen chloride was added to EtOAc (20 mL, 30 mmol, 1.5 M) solution,The resulting mixture was stirred at room temperature for 7 hours.It was then washed with water (50 mL x 2).The combined aqueous phases were adjusted to pH = 10 with saturated aqueous Na 2CO 3.The resulting mixture was treated with DCM/MeOHThe mixed solvent (10/1 (v/v), 150 mL x 4) was extracted.The combined organic phases were dried over anhydrous sodium sulfate.Filter and concentrate under reduced pressure.The residue obtained was subjected to silica gel column chromatography(DCM/NH3 in MeOH (7M) (v/v) = 40/1)To give the title compound as a pale yellow solid (90mg, 33% yield).

Reference： [1]Current Patent Assignee: SHENZHEN DONGYANGGUANG INDUSTRIAL DEVELOPMENT CO LTD - WO2019/99311, 2019, A1 Location in patent: Paragraph 000382
[2]Current Patent Assignee: SHENZHEN DONGYANGGUANG INDUSTRIAL DEVELOPMENT CO LTD; CALITOR SCIENCES LLC - CN109776522, 2019, A Location in patent: Paragraph 0652; 0665; 0666; 0667; 0668

13
[ 1375110-97-6 ]
5-chloro-N₄-(3-ethylpiperidin-4-yl)-N₄-methyl-N₂-(2-methylimidazo[1,2-a]pyridin-7-yl)pyrimidine-2,4-diamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate; palladium diacetate / 1,4-dioxane / Reflux 2: hydrogenchloride / ethyl acetate / 1 h / 20 °C

14
[ 1375110-97-6 ]
6-(4-((5-chloro-2-((2-methylimidazo[1,2-a]pyridin-7-yl)amino)pyrimidin-4-yl)(methyl)amino)-3-ethylpiperidin-1-yl)pyridazine-3-carbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate; palladium diacetate / 1,4-dioxane / Reflux 2: hydrogenchloride / ethyl acetate / 1 h / 20 °C 3: triethylamine / ethanol / 20 °C
	Multi-step reaction with 3 steps 1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate; palladium diacetate / 1,4-dioxane / Reflux 2: hydrogenchloride / ethyl acetate / 1 h / 20 °C 3: triethylamine / ethanol / 20 °C

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P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 1375110-97-6 ] {[proInfo.proName]}

Quality Control of [ 1375110-97-6 ]

Related Doc. of [ 1375110-97-6 ]

Product Details of [ 1375110-97-6 ]

Calculated chemistry of [ 1375110-97-6 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 1375110-97-6 ]

Application In Synthesis of [ 1375110-97-6 ]

[ 1375110-97-6 ] Synthesis Path-Downstream 1~14

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

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