Alternatived Products of [ 1375800-37-5 ]
Product Details of [ 1375800-37-5 ]
CAS No. : | 1375800-37-5 |
MDL No. : | MFCD19313384 |
Formula : |
C10H9FO
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | BEYJLWPCKXPANB-SOFGYWHQSA-N |
M.W : |
164.18
|
Pubchem ID : | 82111258 |
Synonyms : |
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Safety of [ 1375800-37-5 ]
Application In Synthesis of [ 1375800-37-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1375800-37-5 ]
- 1
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[ 1375800-37-5 ]
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[ 1378524-41-4 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1.1: sodium sulfate / dichloromethane / 24 h / 20 °C / Inert atmosphere
2.1: sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere
2.2: 0.17 h / 20 °C
2.3: pH > 10
3.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere |
|
Reference:
[1]Wijtmans, Maikel; Maussang, David; Sirci, Francesco; Scholten, Danny J.; Canals, Meritxell; Mujić-Delić, Azra; Chong, Milagros; Chatalic, Kristell L.S.; Custers, Hans; Janssen, Elwin; De Graaf, Chris; Smit, Martine J.; De Esch, Iwan J.P.; Leurs, Rob
[European Journal of Medicinal Chemistry, 2012, vol. 51, p. 184 - 192]
- 2
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[ 1375800-37-5 ]
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[ 51387-90-7 ]
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C17H23FN2
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With sodium sulfate; In dichloromethane; at 20℃; for 24h;Inert atmosphere; |
General procedure: The amine, the aldehyde and MgSO4 (or Na2SO4) were mixed with dry DCM. The mixture was stirred at room temperature for the indicated time (TLC and NMR were used to monitor imine formation). The reaction mixture was filtered and the collected solid was washed with DCM. The filtrate was concentrated in vacuo. MeOH was added to the residue and the mixture was cooled to 0 C. NaBH4 was added to reduce the imine. The mixture was stirred at 0 C for the indicated time. The reaction mixture was quenched with acetone, stirred for 10 min at room temperature and concentrated in vacuo. Extraction was performed with H2O/DCM (2x) ensuring that the pH of the water layer is >10 by addition of aq. 10% K2CO3-solution. The combined organic layers were washed with brine (1x), dried over Na2SO4, filtered and concentrated in vacuo. If indicated, the crude product was purified. |