Home Cart 0 Sign in  
X

[ CAS No. 1379306-17-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
3d Animation Molecule Structure of 1379306-17-8
Chemical Structure| 1379306-17-8
Chemical Structure| 1379306-17-8
Structure of 1379306-17-8 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 1379306-17-8 ]

Related Doc. of [ 1379306-17-8 ]

Alternatived Products of [ 1379306-17-8 ]
Product Citations

Product Details of [ 1379306-17-8 ]

CAS No. :1379306-17-8 MDL No. :MFCD18073502
Formula : C5H2BrClO2S Boiling Point : -
Linear Structure Formula :- InChI Key :SXQOPHPWZLBIKR-UHFFFAOYSA-N
M.W : 241.49 Pubchem ID :83824911
Synonyms :

Safety of [ 1379306-17-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1379306-17-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1379306-17-8 ]

[ 1379306-17-8 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 24287-95-4 ]
  • C5H2BrClO2S [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-chloro-succinimide; In N,N-dimethyl-formamide; at 80℃; for 1h;Inert atmosphere; To a solution of 1.0 g (4.8 mmol) of <strong>[24287-95-4]2-bromothiophene-3-carboxylic acid</strong> (Aldrich) in N,N-dimethylformamide (16 ml) was added 0.90 g (6.7 mmol) of N-chlorosuccinimide under a nitrogen atmosphere at room temperature while stirring, and the mixture was heated and stirred at 80C for one hour. After completion of the reaction, the reaction mixture was allowed to cool, water was added, acidified by adding 2N hydrochloric acid thereto, and the mixture was extracted with ethyl acetate. The organic layer was washed sequentially with an aqueous sodium hydrogen sulfite solution and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. To a solution of the resulting residue in methylene chloride (15 ml) was added dropwise 0.80 ml (9.1 mmol) of oxalyl chloride under a nitrogen atmosphere at 0C while stirring, the temperature was raised to room temperature, and the mixture was stirred for 30 minutes. Then, 3.7 mL (48 mmol) of 28% by weight aqueous ammonia was added dropwise at room temperature while stirring, and the mixture was stirred at room temperature for one hour. After completion of the reaction, to the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, subsequently dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography (elution solvent; hexane:ethyl acetate = 69:31 to 48:52 (V/V)), and the fractions containing the desired compound were concentrated under reduced pressure to obtain 0.62 g (2.6 mmol, yield 53%) of the title compound as a white solid.
  • 2
  • [ 1379306-17-8 ]
  • [ 1614825-70-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: oxalyl dichloride / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere 2: ammonium hydroxide / water; dichloromethane / 1 h / 20 °C / Inert atmosphere 3: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 4.5 h / 90 °C / Inert atmosphere
  • 3
  • [ 1379306-17-8 ]
  • [ 1614825-77-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: oxalyl dichloride / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere 2: ammonium hydroxide / water; dichloromethane / 1 h / 20 °C / Inert atmosphere 3: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 3 h / 90 °C / Inert atmosphere; Cooling with acetone-dry ice 4: water; sodium hydroxide / ethanol / 2 h / 50 °C
  • 4
  • [ 1379306-17-8 ]
  • [ 1614825-64-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: oxalyl dichloride / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere 2: ammonium hydroxide / water; dichloromethane / 1 h / 20 °C / Inert atmosphere 3: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 3 h / 90 °C / Inert atmosphere; Cooling with acetone-dry ice
  • 5
  • [ 1379306-17-8 ]
  • [ 1431949-13-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: oxalyl dichloride / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere 2: ammonium hydroxide / water; dichloromethane / 1 h / 20 °C / Inert atmosphere
  • 6
  • [ 1379306-17-8 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
With oxalyl dichloride In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere; 21 (Reference Example 21) 2-Bromo-5-chlorothiophene-3-carboxamide To a solution of 1.0 g (4.8 mmol) of 2-bromothiophene-3-carboxylic acid (Aldrich) in N,N-dimethylformamide (16 ml) was added 0.90 g (6.7 mmol) of N-chlorosuccinimide under a nitrogen atmosphere at room temperature while stirring, and the mixture was heated and stirred at 80°C for one hour. After completion of the reaction, the reaction mixture was allowed to cool, water was added, acidified by adding 2N hydrochloric acid thereto, and the mixture was extracted with ethyl acetate. The organic layer was washed sequentially with an aqueous sodium hydrogen sulfite solution and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. To a solution of the resulting residue in methylene chloride (15 ml) was added dropwise 0.80 ml (9.1 mmol) of oxalyl chloride under a nitrogen atmosphere at 0°C while stirring, the temperature was raised to room temperature, and the mixture was stirred for 30 minutes. Then, 3.7 mL (48 mmol) of 28% by weight aqueous ammonia was added dropwise at room temperature while stirring, and the mixture was stirred at room temperature for one hour. After completion of the reaction, to the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, subsequently dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography (elution solvent; hexane:ethyl acetate = 69:31 to 48:52 (V/V)), and the fractions containing the desired compound were concentrated under reduced pressure to obtain 0.62 g (2.6 mmol, yield 53%) of the title compound as a white solid.
  • 7
  • [ 1379306-17-8 ]
  • [ 1614825-69-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: oxalyl dichloride / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere 2: ammonium hydroxide / water; dichloromethane / 1 h / 20 °C / Inert atmosphere 3: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 6 h / 90 °C / Inert atmosphere
Recommend Products
Same Skeleton Products
Historical Records