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Chemical Structure| 1379330-75-2 Chemical Structure| 1379330-75-2

Structure of 1379330-75-2

Chemical Structure| 1379330-75-2

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Product Details of [ 1379330-75-2 ]

CAS No. :1379330-75-2
Formula : C9H9N3O
M.W : 175.19
SMILES Code : O=C(C1=CC2=C(C=C1)C=NN2C)N
MDL No. :MFCD20725792

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Application In Synthesis of [ 1379330-75-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1379330-75-2 ]

[ 1379330-75-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 704-91-6 ]
  • [ 74-89-5 ]
  • [ 1379330-75-2 ]
YieldReaction ConditionsOperation in experiment
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 23℃; for 14h; A mixture of lH-<strong>[704-91-6]indazole-6-carboxylic acid</strong> (4-1, 1.11 g, 6.85 mmol, 1 equiv), N,N-diisopropylethylamine (2.65 g, 20.5 mmol, 3.00 equiv), (lH-l,2,3-benzotriazol-l-yloxy)(tripyrrolidin-l-yl)phosphonium hexafluorophosphate (Pybop, 5.34 g, 10.3 mmol, 1.50 equiv) and methylamine (10.3 mL (2M in THF), 20.5 mmol, 3 .00 equiv) in DMF (10 mL) was stirred at 23 0C for 14 h. The reaction mixture was partitioned between a 1 : 1 aqueous mixture of of sodium chloride solution and sodium bicarbonate solution and ethyl acetate (2 x 50 mL). The aqueous layer was then acidified to pH 5 and washed with ethyl acetate (2 x 50 mL). The combined organic layers were dried over sodium sulfate and concentrated. The residue was purified by flash column chromatography (hexanes initially, grading to 100percent EtOAc, then 10percent MeOH in EtOAc) to give N-methyl-lH-indazole-6-carboxamide (4-2) as a light brown solid. LRMS m/z (M+H) 176.2 found, 176.1 required.
 

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