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Chemical Structure| 1381949-87-6 Chemical Structure| 1381949-87-6

Structure of 1381949-87-6

Chemical Structure| 1381949-87-6

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Product Details of [ 1381949-87-6 ]

CAS No. :1381949-87-6
Formula : C18H24N2O5
M.W : 348.39
SMILES Code : CC(C)(OC(N1CCN(C(OCC2=CC=CC=C2)=O)[C@@H](C=O)C1)=O)C

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Application In Synthesis of [ 1381949-87-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1381949-87-6 ]

[ 1381949-87-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1381949-87-6 ]
  • [ 1159825-06-5 ]
  • C21H29F2N3O6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
320 mg Step 1. (0949) To a stirred solution of <strong>[1159825-06-5]3-amino-2,2-difluoro-propionic acid hydrochloride salt</strong> (400 mg, 1.10 mmol) in DCM (5 mL) was added DIPEA (142 mg, 1.10 mmol) at 0 C., sequentially followed by a solution of compound S (350 mg, 1 mmol) in DCM (5 mL). The reaction mixture was stirred at 0 C. for five minutes. Then NaBH(OAc)3 was added to the mixture. The resulting mixture was stirred at rt overnight. The reaction mixture was partitioned between DCM and water. The organic layer was separated, dried over Na2SO4, concentrated in vacuum and isolated to give compound 96-A-1 (320 mg).
 

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