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Chemical Structure| 1382782-07-1 Chemical Structure| 1382782-07-1

Structure of 1382782-07-1

Chemical Structure| 1382782-07-1

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Product Details of [ 1382782-07-1 ]

CAS No. :1382782-07-1
Formula : C13H13N3O2
M.W : 243.26
SMILES Code : O=C1C2=CC(COC3=CC=CC=C3)=NN2CCN1

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Application In Synthesis of [ 1382782-07-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1382782-07-1 ]

[ 1382782-07-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1382782-07-1 ]
  • [ 37554-70-4 ]
  • [ 1382782-95-7 ]
YieldReaction ConditionsOperation in experiment
33% With caesium carbonate; XPhos;palladium diacetate; at 120℃; for 16.0h;Sealed tube; Inert atmosphere; Palladium (II) acetate (2.79 mg, 0.012 mmol) was added to a stirred suspension of 2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[l,5-a]pyrazin-4-one (100 mg, 0.41 mmol), cesium carbonate (0.18 g, 0.57 mmol), 2-dicyclohexylphosphino-2',4',6'- triisopropylbiphenyl (17 mg, 0.037 mmol) and <strong>[37554-70-4]2-chloro-5-fluoro-4-methoxypyrimidine</strong> (0.2 g, 1.23 mmol) in a sealed tube and under nitrogen. The reaction mixture was stirred at 120 C for 16 hours. The solvent was evaporated in vacuo and the crude product was purified by flash column chromatography (silica; AcOEt in DCM 0/100 to 100/0). The desired fractions were collected and the solvents evaporated in vacuo to yield 5-(5-fluoro-4-methoxy- pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[ 1 ,5-a]pyrazin-4-one (50 mg, 33% yield) as a white solid. 1H NMR (500 MHz, CDC13) delta ppm 4.10 (s, 3 H), 4.41 - 4.57 (m, 4 H), 5.12 (s, 2 H), 6.93 - 7.04 (m, 3 H), 7.09 (s, 1 H), 7.27 - 7.34 (m, 2 H), 8.28 (d, J=2.3 Hz, 1 H).
 

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