Home Cart Sign in  
Chemical Structure| 1382981-69-2 Chemical Structure| 1382981-69-2

Structure of 1382981-69-2

Chemical Structure| 1382981-69-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1382981-69-2 ]

CAS No. :1382981-69-2
Formula : C13H16Cl2N4O2
M.W : 331.20
SMILES Code : CC(O)(C1=NC2=C(Cl)N=C(Cl)N=C2N1C3CCCCO3)C

Safety of [ 1382981-69-2 ]

Application In Synthesis of [ 1382981-69-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1382981-69-2 ]

[ 1382981-69-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 871658-02-5 ]
  • [ 1382981-69-2 ]
  • 2-(6-(2-azabicyclo[2.1.1]hexan-2-yl)-2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)propan-2-ol [ No CAS ]
YieldReaction ConditionsOperation in experiment
79.9% With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20℃; for 16.0h; Example 137 Step 1: 2-(6-(2-azabicyclo[2.1.1]hexan-2-yl)-2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8- yl)propan-2-ol To a solution of 2-(2,6-dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)propan-2-ol (770 mg, 2.32 mmol) and N,N-diisopropylethylamine (899 mg, 6.97 mmol) in acetonitrile (10 rriL) was added <strong>[871658-02-5]2-azabicyclo[2.1.1]hexane hydrochloride</strong> (277 mg, 2.32 mmol). The resulting mixture was stirred at room temperature for 16 h and subsequently concentrated to dryness in vacuo. The resulting mixture was diluted with water and extracted with ethyl acetate (2 x 60 rriL). The combined organic layers were dried over sodium sulfate and concentrated to dryness in vacuo. The resulting residue was purified by column chromatography (silica gel, 200-300 mesh, 30% ethyl acetate in petroleum ether) affording 2-(6-(2-azabicyclo[2.1. l]hexan-2-yl)-2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8- yl)propan-2-ol (700 mg, 79.9%): LCMS (ESI, 5-95AB /1.5 min): RT = 0.834 min, m/z 378.1 [M+H+].
 

Historical Records