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Chemical Structure| 1383776-63-3 Chemical Structure| 1383776-63-3

Structure of 1383776-63-3

Chemical Structure| 1383776-63-3

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Product Details of [ 1383776-63-3 ]

CAS No. :1383776-63-3
Formula : C6H10ClNO
M.W : 147.60
SMILES Code : O=C(Cl)N1C(C)CCC1

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Application In Synthesis of [ 1383776-63-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1383776-63-3 ]

[ 1383776-63-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1383776-63-3 ]
  • [ 51746-85-1 ]
  • [ 1548620-21-8 ]
YieldReaction ConditionsOperation in experiment
80% With pyridine; at 90℃; for 2h; (2-methylpyrrolidin-1 -yl)(4-(pyridin-3.yl)-1 H-lmidazol-1 -yl)methanone Charge 3-(IH-imidazol-4-yI)pyridine (0.3 g, 2.067 mmol) and Pyridine (1.5 ml). Charge 2-methylpyrrolidine-1-carbonyl chloride (0.305 g, 2.067 mmcl). The reaction mixture was heated to 90C and stir for lhr.Sample for TLC. Still starting material, more carbamoyl chloride (0.3g) was added. The mixture was stirred for 1 h and the reaction conversion was checked by TLC (DCM/MeOH, 9:1). No starting material left.The reaction was cooled to room temperature and was diluted with water,then sat NaHCO3 and DCM. The biphasic mixture was separated. The aqueous layer was washed with 0CM. The combined organic layers were washed with sat NaHCO3, dried over Na2SO4, concentrated to dryness. Brownish oil (621mg) was obtained.The product was purified by column chromatography on silica gel (eluent EtOAc thenDCM/MeOH 9:1).An oily material (500mg) was obtained in 80% molar yield; purity >95%13C NMR (150 MHz, CDCI3, 20C) 8: 149.3, 148.5, 146.7, 139.1, 137.2, 132.5, 129.1, 123.6,113.6, 55.8, 50.2, 33.1, 25.1, 19.5
 

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