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Chemical Structure| 1383952-42-8 Chemical Structure| 1383952-42-8

Structure of 1383952-42-8

Chemical Structure| 1383952-42-8

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Product Details of [ 1383952-42-8 ]

CAS No. :1383952-42-8
Formula : C16H21Cl2N3O3
M.W : 374.26
SMILES Code : COC1=CC2=NC=NC(Cl)=C2C=C1OCCCN3CCOCC3.[H]Cl

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1383952-42-8 ]

[ 1383952-42-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 199327-61-2 ]
  • [ 1383952-42-8 ]
YieldReaction ConditionsOperation in experiment
84.1% With triethylamine; trichlorophosphate; In acetonitrile; at 80 - 90℃; for 1h; To the reaction tank into the acetonitrile 1.35L, phosphorus pentachloride 832g,After stirring, 109.3 g of 7-methoxy-6- (3-morpholin-4-ylpropoxy) quinazolin-4 (3H) -one was added, 5 ml of TEA was added,Heating to 80 ~ 90 reaction 1h,TLC monitoring (MeOH: DCM = 1: 5, starting material Rf = 0.4, product Rf = 0.6)The basic material disappeared, 55 ~ 60 vacuum distillation, steaming most of the solvent, distillation finished cooling,Temperature control 20 ~ 25 by adding 3L isopropyl alcohol beating 1h, room temperature filtration, filter cake drying,Dried at 50-60 ° C for 8 h under reduced pressure to give 284.0 g of pale yellow solid, which was gefitinib intermediate 1, the yield was 84.1percent and the HPLC purity was 98.3percent.
 

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