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Chemical Structure| 1383976-62-2 Chemical Structure| 1383976-62-2

Structure of 1383976-62-2

Chemical Structure| 1383976-62-2

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Product Details of [ 1383976-62-2 ]

CAS No. :1383976-62-2
Formula : C9H10FN
M.W : 151.18
SMILES Code : CC1NC2=C(C(F)=CC=C2)C1
MDL No. :N/A

Safety of [ 1383976-62-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Application In Synthesis of [ 1383976-62-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1383976-62-2 ]

[ 1383976-62-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 443-86-7 ]
  • [ 1383976-62-2 ]
  • 2
  • [ 1260383-51-4 ]
  • [ 1383976-62-2 ]
YieldReaction ConditionsOperation in experiment
2.19 g With sodium cyanoborohydride; acetic acid; at 14 - 20℃; for 2h;Inert atmosphere; Step 4a4-Fluoro-2-methyl-2,3-dihydro-1H-indole 3.63 g of sodium cyanoborohydride are gradually added to a solution of 2.87 g of <strong>[1260383-51-4]4-fluoro-2-methylindole</strong> in 98 ml of acetic acid under argon cooled to a temperature of about 14 C. The reaction mixture is left to warm up to ambient temperature. After 2 hours, the reaction mixture is poured into a mixture of water and ice, and is then treated with a 28% aqueous ammonia solution until the pH is 9. The mixture is then extracted twice with dichloromethane. The organic phases are combined, dried over anhydrous magnesium sulfate, filtered, and then concentrated to dryness under reduced pressure. The residue is purified on a 300 g silica column, elution being carried out with a 100/0 to 90/10 v/v heptane/ethyl acetate gradient. 2.19 g of 4-fluoro-2-methyl-2,3-dihydro-1H-indole are thus obtained in the form of a colorless oil, the characteristics of which are the following:1H NMR spectrum (400 MHz): 1.18 (d, J=6.3 Hz, 3H); 2.49 (partially masked dd, J=7.6 and 15.7 Hz, 1H); 3.08 (dd, J=9.0 and 15.7 Hz, 1H); 3.92 (m, 1H); 5.87 (broad s, 1H); 6.20 to 6.31 (m, 2H); 6.90 (td, J=5.9 and 8.1 Hz, 1H)Mass spectrometry: method ARetention time Tr (min)=0.50;[M+H]+: m/z 152
 

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