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Chemical Structure| 1383985-18-9 Chemical Structure| 1383985-18-9

Structure of 1383985-18-9

Chemical Structure| 1383985-18-9

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Product Details of [ 1383985-18-9 ]

CAS No. :1383985-18-9
Formula : C12H17BClNO2
M.W : 253.53
SMILES Code : CC1(C(C)(OB(O1)C2=CN=C(C(Cl)=C2)C)C)C
MDL No. :MFCD16995267
InChI Key :MGYIWQXXNQWRQD-UHFFFAOYSA-N
Pubchem ID :67979439

Safety of [ 1383985-18-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 1383985-18-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1383985-18-9 ]

[ 1383985-18-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1383985-18-9 ]
  • [ 33332-28-4 ]
  • 6-(5-chloro-6-methylpyridin-3-yl)pyrazin-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
53% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water; at 90℃; for 18h;Inert atmosphere; Sealed tube; To a solution of 6-chloropyrazin-2-amine (413 mg, 2.96 mmol) in dioxane (12 mL) in a sealed tube was added 3-chloro-2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (750 mg, 2.96 mmol) and aq. potassium carbonate (2M, 4.44 mL, 8.88 mmol). The reaction was degassed with argon for 5 min and Pd(PPh3)4 (171 mg, 0.148 mmol) was added. The reaction was heated at 90oC for 18 h, cooled to RT, diluted with water (100 mL) and extracted with EA (3x 75 mL). The combined organic layers were dried with MgSO4 and concentrated to a residue which was purified by chromatography eluted with EA/Hep (20:80 to 100:0) to give 6-(5-chloro- 6-methylpyridin-3-yl)pyrazin-2-amine (346 mg, 53percent yield) as a pale yellow solid. LCMS: MH+ 221 and TR = 2.162 min.
 

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