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[ CAS No. 139122-17-1 ] {[proInfo.proName]}

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Chemical Structure| 139122-17-1
Chemical Structure| 139122-17-1
Structure of 139122-17-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 139122-17-1 ]

CAS No. :139122-17-1 MDL No. :
Formula : C17H14ClNO3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 315.75 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 139122-17-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 139122-17-1 ]

[ 139122-17-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 139122-17-1 ]
  • [ 139122-19-3 ]
YieldReaction ConditionsOperation in experiment
84% 3-Chloro-4-[2-(phenylcarbonyloxy)ethyl]-2-oxindole (1.2 g, 4 mmol), 0.15 g of 5% palladium on carbon and 15 mL of methanol was stirred and heated to reflux and 0.4 g (8 mmol) of hydrazine hydrate was slowly added at a rate to control refluxing. The reaction was refluxed for 1 hour, 0.33 g of sodium hydroxide dissolved in 6.6 mL of water was added, and the mixture refluxed for an additional 30 minutes. The hot solution was filtered through a pad of diatomaceous earth to remove the catalyst and distilled to remove most of the methanol solvent. The aqueous residue was allowed to stand overnight at room temperature and then in the refrigerator for 2 hours. The white solids were collected by vacuum filtration, washed twice with water, and dried under vacuum to give 6 g (84% yield) of the title compound, mp 145.1-147.0 C.
71% To 15 ml methanol by adding intermediate 13 (1.20g, 3 . 80mmol), stirred, and added 10% Pd/C (0.075g, 0 . 070mmol), heated to reflux. Slowly dripped in the hydrazine hydrate (0.38g, 7 . 59mmol), refluxed for 3h. Dissolved in 26 ml of water sodium hydroxide (8.10g, 202mmol), and then refluxed for 2h. Hot filtered, concentrated under reduced pressure to remove most of the methanol (solution just beginning to separate out with solid particles), is arranged in the refrigerator in which the cooling 2h. Filtering, cold water wash (2×15 ml), 65 C vacuum drying, to obtain colourless crystal 0.48 g. Yield 71%, melting point 146-147 C (literature 147-149 C).
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