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Chemical Structure| 1392467-08-1 Chemical Structure| 1392467-08-1

Structure of 1392467-08-1

Chemical Structure| 1392467-08-1

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Product Details of [ 1392467-08-1 ]

CAS No. :1392467-08-1
Formula : C10H12N2O
M.W : 176.22
SMILES Code : N#CC1=NC=C(OC(C)(C)C)C=C1
MDL No. :MFCD24218663

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1392467-08-1 ]

[ 1392467-08-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 327056-62-2 ]
  • [ 865-48-5 ]
  • [ 1392467-08-1 ]
YieldReaction ConditionsOperation in experiment
62% In N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; To NaOtBu (1.57 g, 16.4 mmol) in HMPA (6 mL) was added DMF (6 mL) (to facilitate stirring). 5-Fluoropyridine-2-carbonitrile (1.00 g, 8.19 mmol) was added and the dark mixture was stirred overnight. The mixture was diluted with water (100 mL), extracted with DCM (3×50 mL) and the organics were washed with water (50 mL) and sat. aq. NaHCO3 (50 mL), dried over MgSO4, evaporated and purified by column chromatography (0-50% EtOAc/hex) to give 5-tert-butoxypyridine-2-carbonitrile (0.90 g, 62%) as a yellow solid. ESI-MS m/z calc. 211.1. found 211.9 (M+1)+; Retention time: 0.97 minutes (3 min run). 1H NMR (400 MHz, CDCl3) δ 8.38 (dd, J=2.7, 0.5 Hz, 1H), 7.67-7.56 (m, 1H), 7.41-7.31 (m, 1H), 1.52-1.38 (m, 10H).
 

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